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Larder BA

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Publications:

Title Authors Year Journal
Effects of dipeptide insertions between codons 69 and 70 of human immunodeficiency virus type 1 reverse transcriptase on primer unblocking, deoxynucleoside triphosphate inhibition, and DNA chain elongation. Larder BA 2003 J Virol
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215. Larder BA 2002 J Virol
Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants. Larder BA 2001 J Virol
A novel human immunodeficiency virus type 1 reverse transcriptase mutational pattern confers phenotypic lamivudine resistance in the absence of mutation 184V. Larder BA 2000 Antimicrob Agents Chemother
A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance. Larder BA 1999 Antimicrob Agents Chemother
3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes. Larder BA 1998 Proceedings of the National Academy of Sciences of the United States of America
Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility. Larder BA 1996 J Virol
Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy. Larder BA 1995 Science
Novel mutation (V75T) in human immunodeficiency virus type 1 reverse transcriptase confers resistance to 2',3'-didehydro-2',3'-dideoxythymidine in cell culture. Larder BA 1994 Antimicrobial agents and chemotherapy
Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Larder BA 1993 Proceedings of the National Academy of Sciences of the United States of America
3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors. Larder BA 1992 Antimicrob Agents Chemother
Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine. Larder BA 1992 Proceedings of the National Academy of Sciences of the United States of America
Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine. Larder BA 1992 The Journal of biological chemistry
Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. Larder BA 1991 Science
Zidovudine-resistant human immunodeficiency virus selected by passage in cell culture. Larder BA 1991 Journal of virology
Mutations within the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase abolish virus infectivity. Larder BA 1991 The Journal of general virology
Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay. Larder BA 1990 Antimicrob Agents Chemother
Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Larder BA 1989 Science
Site-specific mutagenesis of AIDS virus reverse transcriptase. Larder BA 1987 Nature
Selection and characterisation of acyclovir-resistant herpes simplex virus type 1 mutants inducing altered DNA polymerase activities. Larder BA 1985 Virology
Properties of purified enzymes induced by pathogenic drug-resistant mutants of herpes simplex virus. Evidence for virus variants expressing normal DNA polymerase and altered thymidine kinase. Larder BA 1983 The Journal of biological chemistry

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