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Mellors JW

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Publications:

Title Authors Year Journal
Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs. Mellors JW 2011 Nucleic acids research
The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1. Mellors JW 2005 The Journal of biological chemistry
Relationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase. Mellors JW 2003 J Virol
Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase. Mellors JW 2002 Antimicrob Agents Chemother
Alkylglycerol prodrugs of phosphonoformate are potent in vitro inhibitors of nucleoside-resistant human immunodeficiency virus type 1 and select for resistance mutations that suppress zidovudine resistance. Mellors JW 2001 Antimicrob Agents Chemother
In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine. Mellors JW 2000 Antimicrobial agents and chemotherapy
Stavudine resistance: an update on susceptibility following prolonged therapy. Mellors JW 1999 Antiviral therapy
Impaired fitness of foscarnet-resistant strains of human immunodeficiency virus type 1. Mellors JW 1998 AIDS Res Hum Retroviruses
Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates. Mellors JW 1995 Antimicrob Agents Chemother
Resistance of human immunodeficiency virus type 1 to acyclic 6-phenylselenenyl- and 6-phenylthiopyrimidines. Mellors JW 1994 Antimicrobial agents and chemotherapy
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides. Mellors JW 1993 Antimicrob Agents Chemother
A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5, 1- jk][1,4]benzodiazepin-2(1H)-thione (TIBO R82150). Mellors JW 1993 Molecular pharmacology
In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase. Mellors JW 1992 Mol Pharmacol

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