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Zhang H

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Publications:

Title Authors Year Journal
Structure of a DNA polymerase alpha-primase domain that docks on the SV40 helicase and activates the viral primosome. Zhang H 2010 The Journal of biological chemistry
Effect of N2-guanyl modifications on early steps in catalysis of polymerization by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W. Zhang H 2010 Journal of molecular biology
Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4: guanine N2,N2-dimethyl substitution produces inactive and miscoding polymerase complexes. Zhang H 2009 The Journal of biological chemistry
Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts. Zhang H 2009 The Journal of biological chemistry
Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formation. Zhang H 2009 The Journal of biological chemistry
RB69 DNA polymerase mutants with expanded nascent base-pair-binding pockets are highly efficient but have reduced base selectivity. Zhang H 2009 Biochemistry
Domain architecture and biochemical characterization of vertebrate Mcm10. Zhang H 2008 The Journal of biological chemistry
Fluorescence of 2-aminopurine reveals rapid conformational changes in the RB69 DNA polymerase-primer/template complexes upon binding and incorporation of matched deoxynucleoside triphosphates. Zhang H 2007 Nucleic acids research
The L561A substitution in the nascent base-pair binding pocket of RB69 DNA polymerase reduces base discrimination. Zhang H 2006 Biochemistry
Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant. Zhang H 2002 Eur J Biochem
Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues. Zhang H 1999 J Med Chem
Measurement of deoxyuridine triphosphate and thymidine triphosphate in the extracts of thymidylate synthase-inhibited cells using a modified DNA polymerase assay. Zhang H 1997 Biochem Pharmacol
Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethyl thiazolyl thiourea derivatives trovirdine and MSC-127. Zhang H 1995 Antiviral research
HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase. Zhang H 1993 Virology
Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors. Zhang H 1993 Proceedings of the National Academy of Sciences of the United States of America
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