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Darden TA

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Publications:

Title Authors Year Journal
Reaction mechanism of the epsilon subunit of E. coli DNA polymerase III: insights into active site metal coordination and catalytically significant residues. Darden TA 2009 Journal of the American Chemical Society
Model for the catalytic domain of the proofreading epsilon subunit of Escherichia coli DNA polymerase III based on NMR structural data. Darden TA 2002 Biochemistry
Residues in the alphaH and alphaI helices of the HIV-1 reverse transcriptase thumb subdomain required for the specificity of RNase H-catalyzed removal of the polypurine tract primer. Darden TA 1999 The Journal of biological chemistry
Vertical-scanning mutagenesis of a critical tryptophan in the minor groove binding track of HIV-1 reverse transcriptase. Molecular nature of polymerase-nucleic acid interactions. Darden TA 1998 The Journal of biological chemistry
A minor groove binding track in reverse transcriptase. Darden TA 1997 Nat Struct Biol
Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain. Darden TA 1995 The Journal of biological chemistry
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