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Batra VK

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Publications:

Title Authors Year Journal
A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways. Batra VK Molekuliarnaia biologiia
Amino acid substitution in the active site of DNA polymerase β explains the energy barrier of the nucleotidyl transfer reaction. Batra VK 2013 Journal of the American Chemical Society
β,γ-CHF- and β,γ-CHCl-dGTP diastereomers: synthesis, discrete 31P NMR signatures and absolute configurations of new stereochemical probes for DNA polymerases. Batra VK 2012 Journal of the American Chemical Society
Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion. Batra VK 2011 Proceedings of the National Academy of Sciences of the United States of America
Molecular insights into DNA polymerase deterrents for ribonucleotide insertion. Batra VK 2011 The Journal of biological chemistry
Base excision repair and design of small molecule inhibitors of human DNA polymerase beta. Batra VK 2010 Cell Mol Life Sci
Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues. Batra VK 2010 Journal of the American Chemical Society
Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Batra VK 2010 Proceedings of the National Academy of Sciences of the United States of America
DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine. Batra VK 2010 Mutation research
Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Batra VK 2010 Nature structural & molecular biology
Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Batra VK 2009 Org Lett
DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". Batra VK 2009 The Journal of biological chemistry
Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta. Batra VK 2008 Proceedings of the National Academy of Sciences of the United States of America
Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Batra VK 2008 Molecular cell
The X family portrait: structural insights into biological functions of X family polymerases. Batra VK 2007 DNA repair
(R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. Batra VK 2007 Journal of the American Chemical Society
Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta. Batra VK 2007 Biochemistry
Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Batra VK 2006 Proceedings of the National Academy of Sciences of the United States of America
Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Batra VK 2006 Structure (London, England : 1993)
Energy analysis of chemistry for correct insertion by DNA polymerase beta. Batra VK 2006 Proceedings of the National Academy of Sciences of the United States of America
Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism. Batra VK 2005 DNA repair
Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Batra VK 2005 Structure (London, England : 1993)

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