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Pedersen LC

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Publications:

Title Authors Year Journal
Sustained active site rigidity during synthesis by human DNA polymerase μ. Pedersen LC 2014 Nature structural & molecular biology
Amino acid substitution in the active site of DNA polymerase β explains the energy barrier of the nucleotidyl transfer reaction. Pedersen LC 2013 Journal of the American Chemical Society
Structure-function analysis of ribonucleotide bypass by B family DNA replicases. Pedersen LC 2013 Proceedings of the National Academy of Sciences of the United States of America
The catalytic cycle for ribonucleotide incorporation by human DNA Pol λ Pedersen LC 2012 Nucleic acids research
Replication infidelity via a mismatch with Watson-Crick geometry. Pedersen LC 2011 Proceedings of the National Academy of Sciences of the United States of America
Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Pedersen LC 2010 Nature structural & molecular biology
Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues. Pedersen LC 2010 Journal of the American Chemical Society
Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Pedersen LC 2010 Proceedings of the National Academy of Sciences of the United States of America
Template strand scrunching during DNA gap repair synthesis by human polymerase lambda. Pedersen LC 2009 Nature structural & molecular biology
DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". Pedersen LC 2009 The Journal of biological chemistry
Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Pedersen LC 2009 Org Lett
Reaction mechanism of the epsilon subunit of E. coli DNA polymerase III: insights into active site metal coordination and catalytically significant residues. Pedersen LC 2009 Journal of the American Chemical Society
Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta. Pedersen LC 2008 Proceedings of the National Academy of Sciences of the United States of America
A comparison of BRCT domains involved in nonhomologous end-joining: introducing the solution structure of the BRCT domain of polymerase lambda. Pedersen LC 2008 DNA repair
Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Pedersen LC 2008 Molecular cell
Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda. Pedersen LC 2008 EMBO Rep
Characterization of a replicative DNA polymerase mutant with reduced fidelity and increased translesion synthesis capacity. Pedersen LC 2008 Nucleic acids research
Structural insight into the substrate specificity of DNA Polymerase mu. Pedersen LC 2007 Nature structural & molecular biology
Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta. Pedersen LC 2007 Biochemistry
Role of the catalytic metal during polymerization by DNA polymerase lambda. Pedersen LC 2007 DNA repair
The X family portrait: structural insights into biological functions of X family polymerases. Pedersen LC 2007 DNA repair
(R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. Pedersen LC 2007 Journal of the American Chemical Society
Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Pedersen LC 2006 Structure (London, England : 1993)
Energy analysis of chemistry for correct insertion by DNA polymerase beta. Pedersen LC 2006 Proceedings of the National Academy of Sciences of the United States of America
Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Pedersen LC 2006 Proceedings of the National Academy of Sciences of the United States of America
Promiscuous mismatch extension by human DNA polymerase lambda. Pedersen LC 2006 Nucleic acids research
Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase. Pedersen LC 2006 Cell
Structure of the Escherichia coli DNA polymerase III epsilon-HOT proofreading complex. Pedersen LC 2006 The Journal of biological chemistry
A closed conformation for the Pol lambda catalytic cycle. Pedersen LC 2005 Nature structural & molecular biology
Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Pedersen LC 2005 Structure (London, England : 1993)
Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism. Pedersen LC 2005 DNA repair
Structure-function studies of DNA polymerase lambda. Pedersen LC 2005 DNA repair
A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. Pedersen LC 2004 Molecular cell

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