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Dalal S

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Publications:

Title Authors Year Journal
Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection. Dalal S 2014 The Journal of biological chemistry
Structural changes in the hydrophobic hinge region adversely affect the activity and fidelity of the I260Q mutator of DNA polymerase ß Dalal S 2013 Biochemistry
Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates. Dalal S 2012 Proceedings of the National Academy of Sciences of the United States of America
Substrate-Dependent Millisecond Domain Motions in DNA Polymerase β Dalal S 2012 Journal of molecular biology
DNA polymerase beta is critical for genomic stability of sperm cells. Dalal S 2011 DNA repair
Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation. Dalal S 2010 Cancer research
The I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates. Dalal S 2008 Biochemistry
The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient. Dalal S 2008 Nucleic acids research
The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Dalal S 2007 Molecular and cellular biology
Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation. Dalal S 2005 Proceedings of the National Academy of Sciences of the United States of America
The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry. Dalal S 2005 The Journal of biological chemistry
Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator. Dalal S 2005 Biochemistry
Hinge residue Ile260 of DNA polymerase beta is important for enzyme activity and fidelity. Dalal S 2005 Biochemistry
Is there a link between DNA polymerase beta and cancer? Dalal S 2004 Cell Cycle
The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site. Dalal S 2004 The Journal of biological chemistry
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