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Gearhart PJ

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Publications:

Title Authors Year Journal
DNA polymerase ΞΆ generates tandem mutations in immunoglobulin variable regions. Gearhart PJ 2012 The Journal of experimental medicine
Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes. Gearhart PJ 2008 DNA repair
Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota. Gearhart PJ 2006 DNA repair
DNA polymerase eta contributes to strand bias of mutations of A versus T in immunoglobulin genes. Gearhart PJ 2005 J Immunol
Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification. Gearhart PJ 2005 Proceedings of the National Academy of Sciences of the United States of America
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes. Gearhart PJ 2005 J Exp Med
Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions. Gearhart PJ 2004 J Exp Med
129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. Gearhart PJ 2003 J Exp Med
DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Gearhart PJ 2001 Nat Immunol
Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template. Gearhart PJ 2001 The EMBO journal
Emerging links between hypermutation of antibody genes and DNA polymerases. Gearhart PJ 2001 Nature reviews. Immunology
Disruption of the developmentally regulated Rev3l gene causes embryonic lethality. Gearhart PJ 2000 Current biology : CB
Differential expression of DNA polymerase epsilon in resting and activated B lymphocytes is consistent with an in vivo role in replication and not repair. Gearhart PJ 2000 Mol Immunol
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