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Julias JG

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Publications:

Title Authors Year Journal
The nucleoside analogue D-carba T blocks HIV-1 reverse transcription. Julias JG 2009 Journal of medicinal chemistry
Mutations in the U5 region adjacent to the primer binding site affect tRNA cleavage by human immunodeficiency virus type 1 reverse transcriptase in vivo. Julias JG 2008 Journal of virology
Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme. Julias JG 2007 Journal of medicinal chemistry
The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants. Julias JG 2007 Journal of molecular biology
The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine. Julias JG 2006 Journal of virology
HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Julias JG 2006 ACS Chem Biol
Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization. Julias JG 2006 Virology
Mutations at position 184 of human immunodeficiency virus type-1 reverse transcriptase affect virus titer and viral DNA synthesis. Julias JG 2004 Virology
Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage. Julias JG 2004 J Virol
Mutation of amino acids in the connection domain of human immunodeficiency virus type 1 reverse transcriptase that contact the template-primer affects RNase H activity. Julias JG 2003 J Virol
Mutations in the 5' end of the human immunodeficiency virus type 1 polypurine tract affect RNase H cleavage specificity and virus titer. Julias JG 2003 J Virol
Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo. Julias JG 2002 Proceedings of the National Academy of Sciences of the United States of America
Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity. Julias JG 2002 Biochemistry
Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase. Julias JG 2001 Journal of virology

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