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Quan Y

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Publications:

Title Authors Year Journal
The Effect of Mutations at Position E138 in HIV-1 Reverse Transcriptase and their Interactions with the M184I Mutation in Defining Patterns of Resistance to the Non-Nucleoside Reverse Transcriptase Inhibitors Rilpivirine and Etravirine. Quan Y 2013 Antimicrobial agents and chemotherapy
Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations. Quan Y 2011 Journal of virology
Comparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C. Quan Y 2010 Retrovirology
Differential impact of the HIV-1 non-nucleoside reverse transcriptase inhibitor mutations K103N and M230L on viral replication and enzyme function. Quan Y 2010 The Journal of antimicrobial chemotherapy
Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine. Quan Y 2009 Antimicrobial agents and chemotherapy
Multidrug-resistant variants of HIV type 1 (HIV-1) can exist in cells as defective quasispecies and be rescued by superinfection with other defective HIV-1 variants. Quan Y 2009 The Journal of infectious diseases
Persistence of multidrug-resistant HIV-1 in primary infection leading to superinfection. Quan Y 2004 AIDS (London, England)
Lamivudine can exert a modest antiviral effect against human immunodeficiency virus type 1 containing the M184V mutation. Quan Y 2003 Antimicrobial agents and chemotherapy
Drug resistance profiles of recombinant reverse transcriptases from human immunodeficiency virus type 1 subtypes A/E, B, and C. Quan Y 2003 AIDS research and human retroviruses
Prevalence of HIV-1 resistant to antiretroviral drugs in 81 individuals newly infected by sexual contact or injecting drug use. Investigators of the Quebec Primary Infection Study. Quan Y 2000 AIDS (London, England)
In vitro selection and characterization of HIV-1 with reduced susceptibility to PMPA. Quan Y 1999 Antivir Ther
Selection and characterization of HIV-1 variants resistant to the (+) and (-) enantiomers of 2'-deoxy-3'-oxa-4'-thiocytidine (dOTC). Quan Y 1999 Antiviral therapy
Sensitivity and resistance to (+)-calanolide A of wild-type and mutated forms of HIV-1 reverse transcriptase. Quan Y 1999 Antiviral therapy
Reverse transcriptase inhibitors can selectively block the synthesis of differently sized viral DNA transcripts in cells acutely infected with human immunodeficiency virus type 1. Quan Y 1999 Journal of virology
Dominance of the E89G substitution in HIV-1 reverse transcriptase in regard to increased polymerase processivity and patterns of pausing. Quan Y 1998 The Journal of biological chemistry
Mechanistic studies of early pausing events during initiation of HIV-1 reverse transcription. Quan Y 1998 The Journal of biological chemistry
Enhanced impairment of chain elongation by inhibitors of HIV reverse transcriptase in cell-free reactions yielding longer DNA products. Quan Y 1998 Nucleic acids research
Characterization of human immunodeficiency virus type-1 (HIV-1) particles that express protease-reverse transcriptase fusion proteins. Quan Y 1998 Journal of molecular biology
Endogenous reverse transcriptase assays reveal synergy between combinations of the M184V and other drug resistance-conferring mutations in interactions with nucleoside analog triphosphates. Quan Y 1998 Journal of molecular biology
The importance of the A-rich loop in human immunodeficiency virus type 1 reverse transcription and infectivity. Quan Y 1997 Journal of virology
Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site. Quan Y 1996 Journal of virology
Studies of neutralizing monoclonal antibody to human immunodeficiency virus type 1 reverse transcriptase: antagonistic and synergistic effects in reactions performed in the presence of nucleoside and nonnucleoside inhibitors, respectively. Quan Y 1996 Journal of virology
Endogenous reverse transcription assays reveal high-level resistance to the triphosphate of (-)2'-dideoxy-3'-thiacytidine by mutated M184V human immunodeficiency virus type 1. Quan Y 1996 J Virol
Effects of non-nucleoside inhibitors of human immunodeficiency virus type 1 in cell-free recombinant reverse transcriptase assays. Quan Y 1995 The Journal of biological chemistry
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