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Sluis-Cremer N

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Publications:

Title Authors Year Journal
Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs. Sluis-Cremer N 2011 Nucleic acids research
The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization. Sluis-Cremer N 2010 The Journal of biological chemistry
Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization. Sluis-Cremer N 2006 Journal of medicinal chemistry
The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1. Sluis-Cremer N 2005 The Journal of biological chemistry
Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation. Sluis-Cremer N 2004 The international journal of biochemistry & cell biology
Structure-activity relationships in HIV-1 reverse transcriptase revealed by radiation target analysis. Sluis-Cremer N 2003 Protein science : a publication of the Protein Society
Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors. Sluis-Cremer N 2002 Molecular pharmacology
Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones. Sluis-Cremer N 2002 The Journal of biological chemistry
Mutational analysis of Lys65 of HIV-1 reverse transcriptase. Sluis-Cremer N 2000 Biochem J
Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs). Sluis-Cremer N 2000 Cellular and molecular life sciences : CMLS
Inhibitors of HIV-1 reverse transcriptase. Sluis-Cremer N 2000 Advances in pharmacology (San Diego, Calif.)
Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[Spiro[4"-amino-2",2" -dioxo-1",2" -oxathiole-5",3'-[2', 5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]]-3-ethylthy mine. Sluis-Cremer N 2000 Biochemistry
Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase. Sluis-Cremer N 2000 The Journal of biological chemistry
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