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Himmel DM

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Publications:

Title Authors Year Journal
Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies. Himmel DM 2011 Journal of chemical information and modeling
Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. Himmel DM 2011 Journal of medicinal chemistry
Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site. Himmel DM 2009 Structure (London, England : 1993)
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. Himmel DM 2009 Journal of molecular biology
Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Himmel DM 2008 Nucleic acids research
HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Himmel DM 2006 ACS Chem Biol
Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains. Himmel DM 2005 J Med Chem
4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains. Himmel DM 2005 Journal of medicinal chemistry
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