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Esnouf RM

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Publications:

Title Authors Year Journal
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses. Esnouf RM 2000 The Journal of biological chemistry
Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients. Esnouf RM 2000 AIDS research and human retroviruses
Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies. Esnouf RM 1999 J Med Chem
3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes. Esnouf RM 1998 Proceedings of the National Academy of Sciences of the United States of America
A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152. Esnouf RM 1998 The Journal of general virology
Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives. Esnouf RM 1998 Biochemistry
Models which explain the inhibition of reverse transcriptase by HIV-1-specific (thio)carboxanilide derivatives. Esnouf RM 1997 Biochemical and biophysical research communications
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor. Esnouf RM 1997 Proceedings of the National Academy of Sciences of the United States of America
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. Esnouf RM 1996 J Med Chem
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