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Esnouf RM

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Publications:

Title Authors Year Journal
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses. Esnouf RM 2000 The Journal of biological chemistry
Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients. Esnouf RM 2000 AIDS research and human retroviruses
Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies. Esnouf RM 1999 J Med Chem
3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes. Esnouf RM 1998 Proceedings of the National Academy of Sciences of the United States of America
A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152. Esnouf RM 1998 The Journal of general virology
Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives. Esnouf RM 1998 Biochemistry
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor. Esnouf RM 1997 Proceedings of the National Academy of Sciences of the United States of America
Models which explain the inhibition of reverse transcriptase by HIV-1-specific (thio)carboxanilide derivatives. Esnouf RM 1997 Biochemical and biophysical research communications
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. Esnouf RM 1996 J Med Chem

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