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Kleim JP

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Publications:

Title Authors Year Journal
Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases. Kleim JP 2007 J Med Chem
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. Kleim JP 2001 Journal of molecular biology
Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors. Kleim JP 2000 AIDS research and human retroviruses
A novel genotype encoding a single amino acid insertion and five other substitutions between residues 64 and 74 of the HIV-1 reverse transcriptase confers high-level cross-resistance to nucleoside reverse transcriptase inhibitors. Abacavir CNA2007 International Study Group. Kleim JP 1999 J Acquir Immune Defic Syndr
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance. Kleim JP 1998 Journal of molecular biology
Reverse transcriptase fidelity and HIV-1 variation. Kleim JP 1997 Science (New York, N.Y.)
Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1. Kleim JP 1997 Journal of virology
In vitro selection for different mutational patterns in the HIV-1 reverse transcriptase using high and low selective pressure of the nonnucleoside reverse transcriptase inhibitor HBY 097. Kleim JP 1997 Virology
Zidovudine-resistant human immunodeficiency virus type 1 strains subcultured in the presence of both lamivudine and quinoxaline HBY 097 retain marked sensitivity to HBY 097 but not to lamivudine. Kleim JP 1997 The Journal of infectious diseases
Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants. Kleim JP 1996 Proceedings of the National Academy of Sciences of the United States of America
Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication. Kleim JP 1995 Antimicrobial agents and chemotherapy
Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720. Kleim JP 1994 Journal of virology
Sensitivity of (138 Glu-->Lys) mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to HIV-1-specific RT inhibitors. Kleim JP 1994 Biochemical and biophysical research communications
Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication. Kleim JP 1993 Antimicrobial agents and chemotherapy
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