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McKenna CE

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Publications:

Title Authors Year Journal
β,γ-CHF- and β,γ-CHCl-dGTP diastereomers: synthesis, discrete 31P NMR signatures and absolute configurations of new stereochemical probes for DNA polymerases. McKenna CE 2012 Journal of the American Chemical Society
Effect of β,γ-CHF- and β,γ-CHCl-dGTP Halogen Atom Stereochemistry on the Transition State of DNA Polymerase β McKenna CE 2012 Biochemistry
Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion. McKenna CE 2011 Proceedings of the National Academy of Sciences of the United States of America
Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. McKenna CE 2010 Proceedings of the National Academy of Sciences of the United States of America
Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues. McKenna CE 2010 Journal of the American Chemical Society
Modifications to the dNTP triphosphate moiety: from mechanistic probes for DNA polymerases to antiviral and anti-cancer drug design. McKenna CE 2010 Biochimica et biophysica acta
Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. McKenna CE 2009 Org Lett
A computational study of the hydrolysis of dGTP analogues with halomethylene-modified leaving groups in solution: implications for the mechanism of DNA polymerases. McKenna CE 2009 Biochemistry
DNA polymerase beta fidelity: halomethylene-modified leaving groups in pre-steady-state kinetic analysis reveal differences at the chemical transition state. McKenna CE 2008 Biochemistry
(R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. McKenna CE 2007 Journal of the American Chemical Society
Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta. McKenna CE 2007 Biochemistry
Carbonyldiphosphonate, a selective inhibitor of mammalian DNA polymerase delta. McKenna CE 1989 Biochemistry

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