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Watson KM

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Publications:

Title Authors Year Journal
Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Watson KM 2009 European journal of medicinal chemistry
Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase. Watson KM 2009 J Med Chem
Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors. Watson KM 2008 Bioorganic & medicinal chemistry letters
Inhibition of tubulin polymerization by select alkenyldiarylmethanes. Watson KM 2008 Bioorganic & medicinal chemistry letters
Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability. Watson KM 2007 Journal of medicinal chemistry
Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems. Watson KM 2007 Journal of medicinal chemistry
Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme. Watson KM 2007 Journal of medicinal chemistry

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