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Cancio R

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Publications:

Title Authors Year Journal
AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription. Cancio R 2008 Journal of molecular biology
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. Cancio R 2008 Biochemical pharmacology
NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine. Cancio R 2007 Antiviral research
N2-benzyloxycarbonylguan-9-yl acetic acid derivatives as HIV-1 reverse transcriptase non-nucleoside inhibitors with decreased loss of potency against common drug-resistance mutations. Cancio R 2007 ChemMedChem
Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants. Cancio R 2007 ChemMedChem
Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate. Cancio R 2007 Angewandte Chemie (International ed. in English)
Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 1). Cancio R 2006 ChemMedChem
Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors. Cancio R 2006 ChemMedChem
Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz. Cancio R 2005 Antimicrobial agents and chemotherapy
Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication. Cancio R 2004 Antimicrobial agents and chemotherapy
HIV-1 reverse transcriptase inhibitors: current issues and future perspectives. Cancio R 2004 Current drug metabolism
Vif is an auxiliary factor of the HIV-1 reverse transcriptase and facilitates abasic site bypass. Cancio R 2004 The Biochemical journal
Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex. Cancio R 2004 Antimicrobial agents and chemotherapy

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