TGO

From Thermococcus gorgonarius
show help

Welcome to the Polymerase Page

This page presents all the information in Polbase for TGO.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

Missing mutants?
TGO is a family B enzyme from Thermococcus gorgonarius.

Selected Properties for TGO:

 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Yes (2) no data no data no data no data
Year Authors Title Results by property
2012 Christopher Cozens, Vitor B Pinheiro, Alexandra Vaisman, Roger Woodgate, Philipp Holliger A short adaptive path from DNA to RNA...
2010 Tom Killelea, Samantak Ghosh, Samuel S Tan, Pauline Heslop, Susan J Firbank, Eric T Kool, Bernard A Connolly Probing the interaction of archaeal D...
2009 Henry J Russell, Tomas T Richardson, Kieran Emptage, Bernard A Connolly The 3'-5' proofreading exonuclease of... 3-5' exo,5-3' exo,All properties
2008 Susan J Firbank, Josephine Wardle, Pauline Heslop, Richard J Lewis, Bernard A Connolly Uracil recognition in archaeal DNA po...
2004 Andrew F Gardner, Catherine M Joyce, William E Jack Comparative kinetics of nucleotide an...
1999 K P Hopfner, A Eichinger, R A Engh, F Laue, W Ankenbauer, R Huber, B Angerer Crystal structure of a thermostable t... Cloned or native,Full length or truncated,3-5' exo,Amino Acids Contacting NTP,Amino Acids Contacting Primer,All properties
Protein sequence:

Predicted Structure Model

Predicted model AlphaFold DB Not experimentally determined

This AlphaFold DB model is predicted and not an experimentally determined structure. View AlphaFold DB entry Download predicted model (.pdb)

Confidence legend (pLDDT)

AlphaFold DB colors residues by predicted confidence. Use high-confidence regions for structural context and treat low-confidence regions cautiously.

  • Very high (pLDDT > 90) Backbone and side chains are usually reliable.
  • Confident (pLDDT 70-90) Overall fold is usually reliable, but some local detail may shift.
  • Low (pLDDT 50-70) Use with caution; this region may be flexible or uncertain.
  • Very low (pLDDT < 50) Often disordered or not confidently placed.
2XHB
2VWK
2VWJ
1TGO
Name 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Tgo E664K

Version:20260603

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.