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Welcome to the Polymerase Page

This page presents all the information in Polbase for HIV RT G190E.


At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.


If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

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Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.


All references that refer to this Polymerase are listed with their topics and paper's title in the References table.


All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

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Mutant of: HIV RT (G190E)

HIV RT G190E is a family RT enzyme from HIV. "From the Los Alamos National Labs HIV Mutant database (now offline):|id:549|codon:GGA>GAA|drugs:AAP-BHAP "From the Los Alamos National Labs HIV Mutant database (now offline):|id:550|codon:GGA>GAA|drugs:DMP-266 From the Los Alamos National Labs HIV Mutant database (now offline):|id:551|codon:GGA>GAA|drugs:HBY 097|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Reduces enzymatic activity of RT and viral replication competency "From the Los Alamos National Labs HIV Mutant database (now offline):|id:552|codon:GGA>GAA|drugs:BI-RG-587 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:553|codon:GGA>GAA|drugs:S-2720 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:554|codon:GGA>GAA|drugs:UC-38

Selected Properties for HIV RT G190E:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
2003 Wei Huang, Andrea Gamarnik, Kay Limoli, Christos J Petropoulos, Jeannette M Whitcomb Amino acid substitutions at position ...
2000 L T Bacheler, E D Anton, P Kudish, D Baker, J Bunville, K Krakowski, L Bolling, M Aujay, X V Wang, D Ellis, M F Becker, A L Lasut, H J George, D R Spalding, G Hollis, K Abremski Human immunodeficiency virus type 1 m...
1996 R A Olmsted, D E Slade, L A Kopta, S M Poppe, T J Poel, S W Newport, K B Rank, C Biles, R A Morge, T J Dueweke, Y Yagi, D L Romero, R C Thomas, S K Sharma, W G Tarpley (Alkylamino) piperidine bis(heteroary...
1995 Jörg-Peter Kleim, R Bender, R Kirsch, C Meichsner, A Paessens, M Rösner, H Rübsamen-Waigmann, R Kaiser, M Wichers, K E Schneweis Preclinical evaluation of HBY 097, a ...
1995 Jan Balzarini, María-Jesús Pérez-Pérez, S Vélazquez, Ana San-Félix, María-José Camarasa, Erik De Clercq, Anna Karlsson Suppression of the breakthrough of hu...
1993 Jörg-Peter Kleim, R Bender, U M Billhardt, C Meichsner, G Riess, M Rösner, I Winkler, A Paessens Activity of a novel quinoxaline deriv...

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