From Human herpesvirus 1 (aliases:UL54, HSV1, HSV-1) (genes: UL30)
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Welcome to the Polymerase Page

This page presents all the information in Polbase for HHV1.


At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.


If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.


All references that refer to this Polymerase are listed with their topics and paper's title in the References table.


All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

HHV1 is a family B enzyme from Human herpesvirus 1.

Selected Properties for HHV1:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
Yes (1) no data no data no data no data
Year Authors Title Results by property
2012 Sonia Burrel, Zaïna Aït-Arkoub, Henri Agut, David Boutolleau Genotypic characterization of herpes ...
2011 Abhinav Grover, Vibhuti Agrawal, Ashutosh Shandilya, Virendra S Bisaria, Durai Sundar Non-nucleosidic inhibition of Herpes ...
2009 Wang Tian, Ying T Hwang, Qiangsheng Lu, Charles B C Hwang Finger domain mutation affects enzyme... 3-5' exo,5-3' exo,All properties
2008 Gualtiero Alvisi, Simone Avanzi, Daniele Musiani, Daria Camozzi, Valerio Leoni, Jennifer D Ly-Huynh, Alessandro Ripalti Nuclear import of HSV-1 DNA polymeras...
2006 Arianna Loregian, Alessandro Case, Enrico Cancellotti, Carlo Valente, Howard S Marsden, Giorgio Palù Cloning, expression, and functional c...
2006 Shenping Liu, John D Knafels, Jeanne S Chang, Gregory A Waszak, Eric T Baldwin, Martin R Deibel, Darrell R Thomsen, Fred L Homa, Peter A Wells, Monica C Tory, Roger A Poorman, Hua Gao, Xiayang Qiu, Andrew P Seddon Crystal structure of the herpes simpl...
2005 Kelly S Trego, Yali Zhu, Deborah S Parris The herpes simplex virus type 1 DNA p...
2004 Beatrice D Pilger, Can Cui, Donald M Coen Identification of a small molecule th...
2004 Arianna Loregian, Brent A Appleton, James M Hogle, Donald M Coen Specific residues in the connector lo...
2002 Giuseppe Villani, Nicolas Tanguy Le Gac, Luc Wasungu, Dominique Y Burnouf, Robert P P Fuchs, Paul E Boehmer Effect of manganese on in vitro repli...
2000 H J Zuccola, David J Filman, Donald M Coen, James M Hogle The crystal structure of an unusual p... Cloned or native,Full length or truncated,All properties
1985 K B Frank, J F Chiou, Yung-Chi Cheng Interaction of DNA polymerase and nuc...
1979 P F Pignatti, E Cassai, U Bertazzoni Herpes simplex virus DNA synthesis in...
Protein sequence:
Name 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
HHV1 L774F No (1)
HHV1 YD12 No (1)

Using Polbase tables:


Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).


It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.