HIV RT K101E

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This page presents all the information in Polbase for HIV RT K101E.

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Mutant of: HIV RT (K101E)

HIV RT K101E is a family RT enzyme from HIV. From the Los Alamos National Labs HIV Mutant database (now offline):|id:918|codon:AAA>GAA|drugs:MSK-076|class:noncompetitive RT inhibitor|notes:HIV-1 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:386|codon:AAA>GAA|drugs:ADAMII|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:>30-fold resistant against a virus isolate "From the Los Alamos National Labs HIV Mutant database (now offline):|id:388|codon:AAA>GAA|drugs:BI-RG-587 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:389|codon:AAA>GAA|drugs:DMP-266 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:390|codon:AAA>GAA|drugs:L-697 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:391|codon:AAA>GAA|drugs:UC-10 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:392|codon:AAA>GAA|drugs:UC-38 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:393|codon:AAA>GAA|drugs:UC-57 From the Los Alamos National Labs HIV Mutant database (now offline):|id:394|codon:AAA>GAA|drugs:UC-781|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:By passage 15: Y181C/V108I/K101E: >500-fold "From the Los Alamos National Labs HIV Mutant database (now offline):|id:395|codon:AAA>GAA|drugs:UCO40

Selected Properties for HIV RT K101E:

 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
2006 Jingshan Ren, Charles E Nichols, Anna Stamp, Phillip P Chamberlain, Robert G Ferris, Kurt L Weaver, Steven A Short, David K Stammers Structural insights into mechanisms o... RT,All properties
2004 Joeri Auwerx, Miguel Stevens, An R Van Rompay, Louise E Bird, Jingshan Ren, Erik De Clercq, Bo Oberg, David K Stammers, Anna Karlsson, Jan Balzarini The phenylmethylthiazolylthiourea non...
2000 L T Bacheler, E D Anton, P Kudish, D Baker, J Bunville, K Krakowski, L Bolling, M Aujay, X V Wang, D Ellis, M F Becker, A L Lasut, H J George, D R Spalding, G Hollis, K Abremski Human immunodeficiency virus type 1 m...
1998 Mark Cushman, A Casimiro-Garcia, E Hejchman, J A Ruell, M Huang, C A Schaeffer, K Williamson, W G Rice, Robert W Buckheit New alkenyldiarylmethanes with enhanc...
1997 Robert W Buckheit, M J Snow, V Fliakas-Boltz, T L Kinjerski, J D Russell, L A Pallansch, W G Brouwer, S S Yang Highly potent oxathiin carboxanilide ...
1995 Jan Balzarini, María-Jesús Pérez-Pérez, S Vélazquez, Ana San-Félix, María-José Camarasa, Erik De Clercq, Anna Karlsson Suppression of the breakthrough of hu...
1995 S D Young, S F Britcher, L O Tran, L S Payne, W C Lumma, T A Lyle, J R Huff, P S Anderson, David B Olsen, Steven S Carroll L-743, 726 (DMP-266): a novel, highly...
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Structure-activity and cross-resistan...
1993 V W Byrnes, V V Sardana, W A Schleif, J H Condra, J A Waterbury, J A Wolfgang, W J Long, C L Schneider, A J Schlabach, B S Wolanski Comprehensive mutant enzyme and viral...

Version:20241007

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