HIV RT Y188C

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This page presents all the information in Polbase for HIV RT Y188C.

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Mutant of: HIV RT (Y188C)

HIV RT Y188C is a family RT enzyme from HIV. From the Los Alamos National Labs HIV Mutant database (now offline):|id:531|codon:TAT>TGT|drugs:ADAMII|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:6.07-fold. Tested against a site-directed mutant. "From the Los Alamos National Labs HIV Mutant database (now offline):|id:532|codon:TAT>TGT|drugs:BI-RG-587 From the Los Alamos National Labs HIV Mutant database (now offline):|id:533|codon:TAT>TGT|drugs:E-EPSeU|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Y188C is the predominant mutation for E-EPSeU; Y188C confers greater resistance than Y181C From the Los Alamos National Labs HIV Mutant database (now offline):|id:534|codon:TAT>TGT|drugs:E-EPU|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Y188C confers greater resistance than Y181C From the Los Alamos National Labs HIV Mutant database (now offline):|id:535|codon:TAT>TGT|drugs:HEPT|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Y188C confers greater resistance than Y181C

Selected Properties for HIV RT Y188C:

 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
2001 Jingshan Ren, C Nichols, L Bird, P Chamberlain, Kurt L Weaver, S Short, David I Stuart, David K Stammers Structural mechanisms of drug resista...
1998 Mark Cushman, A Casimiro-Garcia, E Hejchman, J A Ruell, M Huang, C A Schaeffer, K Williamson, W G Rice, Robert W Buckheit New alkenyldiarylmethanes with enhanc...
1994 Douglas D Richman, D Havlir, J Corbeil, D Looney, C Ignacio, S A Spector, J Sullivan, S Cheeseman, K Barringer, D Pauletti Nevirapine resistance mutations of hu...
1994 M H Nguyen, Raymond F Schinazi, C Shi, N M Goudgaon, P M McKenna, John W Mellors Resistance of human immunodeficiency ...
1994 M H Nguyen, Raymond F Schinazi, C Shi, N M Goudgaon, P M McKenna, John W Mellors Resistance of human immunodeficiency ...
1993 Jan Balzarini, Anna Karlsson, Erik De Clercq Human immunodeficiency virus type 1 d...

Version:20241218

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