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Reference: Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta.

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Polymerase Reference Property Result Context
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. KM 1.7n/a Reaction: Nucleotide incorporation; Substrate: dATP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. KM 55n/a Reaction: Nucleotide incorporation; Substrate: dCTP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. KM 3.2n/a Reaction: Nucleotide incorporation; Substrate: dGTP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. KM 38n/a Reaction: Nucleotide incorporation; Substrate: dTTP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Vmax 4 /minute Reaction: Nucleotide incorporation; Substrate: dATP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Vmax 2.2 /minute Reaction: Nucleotide incorporation; Substrate: dCTP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Vmax 3.6 /minute Reaction: Nucleotide incorporation; Substrate: dGTP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Vmax 2.1 /minute Reaction: Nucleotide incorporation; Substrate: dTTP
Human Pol eta Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Associated condition UV sensitivity
Pol eta Y52E Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. 3-5' Exonuclease (proofreading) No
Pol eta Y52E Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Cloned or native Cloned in yeast
Pol eta Y52E Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. 5-3' Exonuclease No
Pol eta Y52E Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Pol eta Y52E Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. KM 3129n/a Reaction: Nucleotide incorporation; Substrate: dTTP
Pol eta Y52E Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. KM 32n/a Reaction: Nucleotide incorporation; Substrate: dGTP
Pol eta Y52E Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. KM 448n/a Reaction: Nucleotide incorporation; Substrate: dCTP
Pol eta Y52E Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. KM 3.93n/a Reaction: Nucleotide incorporation; Substrate: dATP
Pol eta Y52E Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Vmax 1.3 /minute Reaction: Nucleotide incorporation; Substrate: dATP
Pol eta Y52E Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Vmax 0.5 /minute Reaction: Nucleotide incorporation; Substrate: dCTP
Pol eta Y52E Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Vmax 3.5 /minute Reaction: Nucleotide incorporation; Substrate: dGTP
Pol eta Y52E Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Vmax 2.1 /minute Reaction: Nucleotide incorporation; Substrate: dTTP
Pol eta Y52E Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Associated condition UV sensitivity
Pol eta Y52D Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Cloned or native Cloned in yeast
Pol eta Y52D Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Pol eta Y52D Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Associated condition UV sensitivity
Pol eta Y52H Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Cloned or native Cloned in yeast
Pol eta Y52H Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Pol eta Y52H Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Associated condition UV sensitivity
Pol eta Y52F Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. 3-5' Exonuclease (proofreading) No
Pol eta Y52F Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Cloned or native Cloned in yeast
Pol eta Y52F Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. 5-3' Exonuclease No
Pol eta Y52F Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Pol eta Y52F Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Associated condition UV sensitivity
Pol eta Y52A Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. 3-5' Exonuclease (proofreading) No
Pol eta Y52A Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Cloned or native Cloned in yeast
Pol eta Y52A Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. 5-3' Exonuclease No
Pol eta Y52A Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dNTPs; DNA lesion: TT Cyclobutane Pyrimidine Dimer
Pol eta Y52A Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. Associated condition UV sensitivity

Version:20240415

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.