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Reference: Yamtich J2010, Polymerase: Human Pol beta

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Polymerase Reference Property Result Context
Human Pol beta Yamtich J2010 Full length or truncated Full length
Human Pol beta Yamtich J2010 Template lesions Bypasses Reaction: Nucleotide incorporation
Human Pol beta Yamtich J2010 Template lesions Bypasses Reaction: Nucleotide incorporation; Substrate: dCTP; DNA lesion: 8-oxo-dG
Human Pol beta Yamtich J2010 Template lesions Bypasses Reaction: Nucleotide incorporation
Human Pol beta Yamtich J2010 Strand Displacement Yes
Human Pol beta Yamtich J2010 5-3' Exonuclease No
Human Pol beta Yamtich J2010 3-5' Exonuclease (proofreading) No
Human Pol beta Yamtich J2010 Associated condition I260M and K289M - Cancer
Human Pol beta Yamtich J2010 Amino Acids Contacting Primer Tyr271
Human Pol beta Yamtich J2010 Overall Error Rate 0.0005 errors/bp
Human Pol beta Yamtich J2010 Overall Error Rate 0.0024 errors/bp
Human Pol beta Yamtich J2010 Amino Acids Contacting Template Arg283 and Tyr271
Human Pol beta Yamtich J2010 Other Important Residues Tyr271, Phe272, Asp276, and Asn279 = dNTP binding pocket; Tyr271 = important for both chemistry and dNTP binding, alters steady-state catalytic efficiency
Human Pol beta Yamtich J2010 Amino Acids Contacting NTP Phe272, Asp276 and Asn279
Human Pol beta Yamtich J2010 Molecular Weight 39kD

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.