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Singh K

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Publications:

Title Authors Year Journal
Effects of 4' - and 2-Substitutions on the Bioactivity of 4' -Ethynyl-2-Fluoro-2' -Deoxyadenosine. Singh K 2013 Antimicrobial agents and chemotherapy
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA. Singh K 2013 Retrovirology
Biochemical Mechanism of HIV-1 Resistance to Rilpivirine. Singh K 2012 The Journal of biological chemistry
HIV-1 reverse transcriptase (RT) polymorphism 172K, suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and nonnucleoside RT inhibitors. Singh K 2012 The Journal of biological chemistry
SARS-CoV Replication Inhibitor that Interferes with the Nucleic acid Unwinding of the Viral Helicase. Singh K 2012 Antimicrobial agents and chemotherapy
Characterization of catalytic carboxylate triad in non-replicative DNA polymerase III (pol E) of Geobacillus kaustophilus HTA. Singh K 2012 Cellular and molecular biology (Noisy-le-Grand, France)
Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase. Singh K 2012 Antimicrobial agents and chemotherapy
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase. Singh K 2011 Nucleic acids research
K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism. Singh K 2011 PloS one
The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase. Singh K 2011 Cellular and molecular biology (Noisy-le-Grand, France)
The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine. Singh K 2010 The Journal of biological chemistry
A new DNA polymerase I from Geobacillus caldoxylosilyticus TK4: cloning, characterization, and mutational analysis of two aromatic residues. Singh K 2009 Appl Microbiol Biotechnol
Identification of a new motif required for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I (Klenow fragment): the RRRY motif is necessary for the binding of single-stranded DNA substrate and the template strand of the mismatched duplex. Singh K 2008 The Journal of biological chemistry
Participation of the fingers subdomain of Escherichia coli DNA polymerase I in the strand displacement synthesis of DNA. Singh K 2007 The Journal of biological chemistry
Contribution of polar residues of the J-helix in the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I (Klenow fragment): Q677 regulates the removal of terminal mismatch. Singh K 2005 Biochemistry
Phe 771 of Escherichia coli DNA polymerase I (Klenow fragment) is the major site for the interaction with the template overhang and the stabilization of the pre-polymerase ternary complex. Singh K 2003 Biochemistry
Presence of 18-A long hydrogen bond track in the active site of Escherichia coli DNA polymerase I (Klenow fragment). Its requirement in the stabilization of enzyme-template-primer complex. Singh K 2003 The Journal of biological chemistry
Lysine 152 of MuLV reverse transcriptase is required for the integrity of the active site. Singh K 2002 Biochemistry
DNA polymerase I of Mycobacterium tuberculosis: functional role of a conserved aspartate in the hinge joining the M and N helices. Singh K 2002 The Journal of biological chemistry
The J-helix of Escherichia coli DNA polymerase I (Klenow fragment) regulates polymerase and 3'- 5'-exonuclease functions. Singh K 2000 The Journal of biological chemistry
Role of Q190 of MuLV RT in ddNTP resistance and fidelity of DNA synthesis: a molecular model of interactions with substrates. Singh K 2000 Protein engineering
A carboxylate triad is essential for the polymerase activity of Escherichia coli DNA polymerase I (Klenow fragment). Presence of two functional triads at the catalytic center. Singh K 2000 The Journal of biological chemistry
Analysis of the role of glutamine 190 in the catalytic mechanism of murine leukemia virus reverse transcriptase. Singh K 1999 The Journal of biological chemistry
Tyrosine 222, a member of the YXDD motif of MuLV RT, is catalytically essential and is a major component of the fidelity center. Singh K 1999 Biochemistry
A unified DNA- and dNTP-binding mode for DNA polymerases. Singh K 1998 Trends in biochemical sciences

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