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Brown JA

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Publications:

Title Authors Year Journal
Unlocking the sugar "steric gate" of DNA polymerases. Brown JA 2011 Biochemistry
Pre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide analogs catalyzed by human X- and Y-family DNA polymerases. Brown JA 2011 Antimicrobial agents and chemotherapy
Efficiency and fidelity of human DNA polymerases λ and β during gap-filling DNA synthesis. Brown JA 2011 DNA repair
Kinetic basis of nucleotide selection employed by a protein template-dependent DNA polymerase. Brown JA 2010 Biochemistry
Identification of critical residues for the tight binding of both correct and incorrect nucleotides to human DNA polymerase lambda. Brown JA 2010 Journal of molecular biology
Pre-Steady-State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta. Brown JA 2010 J Nucleic Acids
A novel mechanism of sugar selection utilized by a human X-family DNA polymerase. Brown JA 2010 Journal of molecular biology
Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4. Brown JA 2010 The EMBO journal
Polymerization fidelity of a replicative DNA polymerase from the hyperthermophilic archaeon Sulfolobus solfataricus P2. Brown JA 2009 Biochemistry
Mechanistic studies of the bypass of a bulky single-base lesion catalyzed by a Y-family DNA polymerase. Brown JA 2009 The Journal of biological chemistry
Global conformational dynamics of a Y-family DNA polymerase during catalysis. Brown JA 2009 PLoS Biol
Probing conformational changes of human DNA polymerase lambda using mass spectrometry-based protein footprinting. Brown JA 2009 Journal of molecular biology
Elucidating the kinetic mechanism of DNA polymerization catalyzed by Sulfolobus solfataricus P2 DNA polymerase B1. Brown JA 2009 Biochemistry
Mechanism of double-base lesion bypass catalyzed by a Y-family DNA polymerase. Brown JA 2008 Nucleic acids research
Mechanistic consequences of temperature on DNA polymerization catalyzed by a Y-family DNA polymerase. Brown JA 2008 Nucleic acids research
Kinetic investigation of the inhibitory effect of gemcitabine on DNA polymerization catalyzed by human mitochondrial DNA polymerase. Brown JA 2008 The Journal of biological chemistry
Mechanism of template-independent nucleotide incorporation catalyzed by a template-dependent DNA polymerase. Brown JA 2007 Journal of molecular biology
Single-turnover kinetic analysis of the mutagenic potential of 8-oxo-7,8-dihydro-2'-deoxyguanosine during gap-filling synthesis catalyzed by human DNA polymerases lambda and beta. Brown JA 2007 Journal of molecular biology
Saccharomyces cerevisiae DNA polymerase epsilon and polymerase sigma interact physically and functionally, suggesting a role for polymerase epsilon in sister chromatid cohesion. Brown JA 2003 Molecular and cellular biology
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