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Schlick T

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Publications:

Title Authors Year Journal
Perspective: pre-chemistry conformational changes in DNA polymerase mechanisms. Schlick T 2012 Theoretical chemistry accounts
Unfavorable electrostatic and steric interactions in DNA polymerase β E295K mutant interfere with the enzyme's pathway. Schlick T 2012 Journal of the American Chemical Society
Modeling DNA polymerase μ motions: subtle transitions before chemistry. Schlick T 2010 Biophysical journal
Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda. Schlick T 2008 EMBO Rep
Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization. Schlick T 2008 Journal of the American Chemical Society
A quantum mechanical investigation of possible mechanisms for the nucleotidyl transfer reaction catalyzed by DNA polymerase beta. Schlick T 2007 J Phys Chem B
DNA polymerase beta catalysis: are different mechanisms possible? Schlick T 2007 Journal of the American Chemical Society
Differing conformational pathways before and after chemistry for insertion of dATP versus dCTP opposite 8-oxoG in DNA polymerase beta. Schlick T 2007 Biophys J
Distinct energetics and closing pathways for DNA polymerase beta with 8-oxoG template and different incoming nucleotides. Schlick T 2007 BMC Struct Biol
Sequential side-chain residue motions transform the binary into the ternary state of DNA polymerase lambda. Schlick T 2006 Biophys J
Subtle but variable conformational rearrangements in the replication cycle of Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) may accommodate lesion bypass. Schlick T 2006 Protein science : a publication of the Protein Society
In silico studies of the African swine fever virus DNA polymerase X support an induced-fit mechanism. Schlick T 2006 Biophys J
Correct and incorrect nucleotide incorporation pathways in DNA polymerase beta. Schlick T 2006 Biochem Biophys Res Commun
Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection. Schlick T 2006 Biochemistry
Mismatch-induced conformational distortions in polymerase beta support an induced-fit mechanism for fidelity. Schlick T 2005 Biochemistry
Fidelity discrimination in DNA polymerase beta: differing closing profiles for a mismatched (G:A) versus matched (G:C) base pair. Schlick T 2005 Journal of the American Chemical Society
Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase beta's closing. Schlick T 2004 Proceedings of the National Academy of Sciences of the United States of America
In silico evidence for DNA polymerase-beta's substrate-induced conformational change. Schlick T 2004 Biophys J
Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses. Schlick T 2004 Biophys J
Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly. Schlick T 2004 Journal of the American Chemical Society
Polymerase beta simulations suggest that Arg258 rotation is a slow step rather than large subdomain motions per se. Schlick T 2002 Journal of molecular biology
Local deformations revealed by dynamics simulations of DNA polymerase Beta with DNA mismatches at the primer terminus. Schlick T 2002 Journal of molecular biology
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