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Anderson KS

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Publications:

Title Authors Year Journal
Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection. Anderson KS 2014 The Journal of biological chemistry
Extension into the entrance channel of HIV-1 reverse transcriptase-Crystallography and enhanced solubility. Anderson KS 2013 Bioorganic & medicinal chemistry letters
Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients. Anderson KS 2012 Human molecular genetics
Balancing Antiviral Potency and Host Toxicity: Identifying a Nucleotide Inhibitor with an Optimal Kinetic Phenotype for HIV-1 Reverse Transcriptase. Anderson KS 2012 Molecular pharmacology
The Mechanism of Interaction of Human Mitochondrial DNA Polymerase γ with the Novel Nucleoside Reverse Transcriptase Inhibitor 4' -Ethynyl-2-Fluoro-2' -Deoxyadenosine Indicates a Low Potential for Host Toxicity. Anderson KS 2011 Antimicrobial agents and chemotherapy
A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial disease. Anderson KS 2010 Biochimica et biophysica acta
mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae. Anderson KS 2010 Human molecular genetics
R964C mutation of DNA polymerase gamma imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activity. Anderson KS 2009 Antimicrob Agents Chemother
Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine. Anderson KS 2007 Antimicrob Agents Chemother
Highly selective action of triphosphate metabolite of 4'-ethynyl D4T: a novel anti-HIV compound against HIV-1 RT. Anderson KS 2007 Antiviral Res
Interaction of 2'-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma. Anderson KS 2007 Antivir Chem Chemother
Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase. Anderson KS 2004 Antimicrobial agents and chemotherapy
Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP. Anderson KS 2004 Antiviral Res
Characterization of novel reverse transcriptase and other RNA-associated catalytic activities by human DNA polymerase gamma: importance in mitochondrial DNA replication. Anderson KS 2003 The Journal of biological chemistry
Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase. Anderson KS 2003 Antivir Chem Chemother
Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis. Anderson KS 2003 Biochemistry
Mechanistic studies to understand the progressive development of resistance in human immunodeficiency virus type 1 reverse transcriptase to abacavir. Anderson KS 2002 The Journal of biological chemistry
Perspectives on the molecular mechanism of inhibition and toxicity of nucleoside analogs that target HIV-1 reverse transcriptase. Anderson KS 2002 Biochimica et biophysica acta
Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase. Anderson KS 2001 The Journal of biological chemistry
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine. Anderson KS 2001 Antimicrobial agents and chemotherapy
Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity. Anderson KS 2001 The Journal of biological chemistry
Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs. Anderson KS 2001 The Journal of biological chemistry
Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase. Anderson KS 1999 Biochemistry
Implication of the tRNA initiation step for human immunodeficiency virus type 1 reverse transcriptase in the mechanism of 3'-azido-3'-deoxythymidine (AZT) resistance. Anderson KS 1998 Biochemistry
Pre-steady-state kinetic characterization of wild type and 3'-azido-3'-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance. Anderson KS 1997 Biochemistry
HIV-1 reverse transcriptase resistance to nonnucleoside inhibitors. Anderson KS 1996 Biochemistry
Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. Anderson KS 1995 Science
Mechanism and fidelity of HIV reverse transcriptase. Anderson KS 1992 The Journal of biological chemistry

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