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Cheng YC

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Publications:

Title Authors Year Journal
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile. Cheng YC 2009 Antimicrobial agents and chemotherapy
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate. Cheng YC 2008 Antimicrobial agents and chemotherapy
Highly selective action of triphosphate metabolite of 4'-ethynyl D4T: a novel anti-HIV compound against HIV-1 RT. Cheng YC 2007 Antiviral Res
Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine. Cheng YC 2007 Antimicrob Agents Chemother
4'-Ethynylstavudine (4'-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants. Cheng YC 2005 Antivir Chem Chemother
Reverse transcriptase activity of hepatitis B virus (HBV) DNA polymerase within core capsid: interaction with deoxynucleoside triphosphates and anti-HBV L-deoxynucleoside analog triphosphates. Cheng YC 2004 Mol Pharmacol
A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5, 1- jk][1,4]benzodiazepin-2(1H)-thione (TIBO R82150). Cheng YC 1993 Molecular pharmacology
In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase. Cheng YC 1992 Mol Pharmacol
Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyl)adenine. Cheng YC 1991 The Journal of biological chemistry
Effect of phosphorothioate homo-oligodeoxynucleotides on herpes simplex virus type 2-induced DNA polymerase. Cheng YC 1989 The Journal of biological chemistry
Identification and some properties of a unique DNA polymerase from cells infected with human B-lymphotropic virus. Cheng YC 1989 J Virol
Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition. Cheng YC 1988 Proceedings of the National Academy of Sciences of the United States of America
Interaction of Epstein-Barr virus DNA polymerase with aphidicolin, phosphonoformate and 5'-GMP. Cheng YC 1988 Virus genes
Association of Epstein-Barr virus early antigen diffuse component and virus-specified DNA polymerase activity. Cheng YC 1987 J Virol
Demonstration of Epstein-Barr virus-specific DNA polymerase in chemically induced Raji cells and its antibody in serum from patients with nasopharyngeal carcinoma. Cheng YC 1986 Cancer research
Inhibition of herpes simplex virus DNA polymerase by purine ribonucleoside monophosphates. Cheng YC 1986 The Journal of biological chemistry
Mutually exclusive inhibition of herpesvirus DNA polymerase by aphidicolin, phosphonoformate, and acyclic nucleoside triphosphates. Cheng YC 1985 Antimicrob Agents Chemother
Demonstration of a stimulatory protein for virus-specified DNA polymerase in phorbol ester-treated Epstein-Barr virus-carrying cells. Cheng YC 1985 Proceedings of the National Academy of Sciences of the United States of America
Human cytomegalovirus-induced DNA polymerase and its interaction with the triphosphates of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil, -5-iodocytosine, and -5-methylcytosine. Cheng YC 1985 J Virol
Interaction of Epstein-Barr virus DNA polymerase and 5'-triphosphates of several antiviral nucleoside analogs. Cheng YC 1985 Antimicrob Agents Chemother
Inhibition of cellular DNA polymerase alpha and human cytomegalovirus-induced DNA polymerase by the triphosphates of 9-(2-hydroxyethoxymethyl)guanine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine. Cheng YC 1985 J Virol
Interaction of DNA polymerase and nucleotide analog triphosphates. Cheng YC 1985 Adv Enzyme Regul
Novel interaction of aphidicolin with herpes simplex virus DNA polymerase and polymerase-associated exonuclease. Cheng YC 1984 The Journal of biological chemistry
Interaction of herpes simplex virus-induced DNA polymerase with 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate. Cheng YC 1984 The Journal of biological chemistry
Properties of purified enzymes induced by pathogenic drug-resistant mutants of herpes simplex virus. Evidence for virus variants expressing normal DNA polymerase and altered thymidine kinase. Cheng YC 1983 The Journal of biological chemistry
Herpes simplex virus type I DNA polymerase. Kinetic properties of the associated 3'-5' exonuclease activity and its role in araAMP incorporation. Cheng YC 1981 The Journal of biological chemistry
The role of deoxyuridine triphosphate nucleotidohydrolase, uracil-DNA glycosylase, and DNA polymerase alpha in the metabolism of FUdR in human tumor cells. Cheng YC 1980 Mol Pharmacol
Properties of herpes simplex virus type 1 and type 2 DNA polymerase. Cheng YC 1980 Biochimica et biophysica acta
Properties of herpesvirus-specific thymidine kinase, DNA polymerase and DNase and their implication in the development of specific antiherpes agents. Cheng YC 1979 Adv Ophthalmol
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