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Spratt TE

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Publications:

Title Authors Year Journal
Low fidelity bypass of O2-(3-pyridyl)-4-oxobutylthymine, the most persistent bulky adduct produced by the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by model polymerases. Spratt TE 2012 Chemical research in toxicology
Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase beta and ligase III/XRCC1. Spratt TE 2010 Biochemistry
Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus. Spratt TE 2009 Biochemistry
Identifying the features of purine dNTPs that allow accurate and efficient DNA replication by herpes simplex virus I DNA polymerase. Spratt TE 2009 Biochemistry
Formation of purine-purine mispairs by Sulfolobus solfataricus DNA polymerase IV. Spratt TE 2008 Biochemistry
Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity. Spratt TE 2007 Biochemistry
Structure of purine-purine mispairs during misincorporation and extension by Escherichia coli DNA polymerase I. Spratt TE 2006 Biochemistry
Evidence for a Watson-Crick hydrogen bonding requirement in DNA synthesis by human DNA polymerase kappa. Spratt TE 2005 Molecular and cellular biology
Fidelity of mispair formation and mispair extension is dependent on the interaction between the minor groove of the primer terminus and Arg668 of DNA polymerase I of Escherichia coli. Spratt TE 2005 Biochemistry
Escherichia coli DNA polymerase I (Klenow fragment) uses a hydrogen-bonding fork from Arg668 to the primer terminus and incoming deoxynucleotide triphosphate to catalyze DNA replication. Spratt TE 2004 The Journal of biological chemistry
Yeast DNA polymerase eta makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate. Spratt TE 2003 Proceedings of the National Academy of Sciences of the United States of America
Identification of hydrogen bonds between Escherichia coli DNA polymerase I (Klenow fragment) and the minor groove of DNA by amino acid substitution of the polymerase and atomic substitution of the DNA. Spratt TE 2001 Biochemistry
Klenow fragment-DNA interaction required for the incorporation of nucleotides opposite guanine and O6-methylguanine. Spratt TE 1997 Biochemistry
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