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Longley MJ

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Publications:

Title Authors Year Journal
Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations. Longley MJ 2010 Methods
Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Longley MJ 2009 Nucleic acids research
Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication. Longley MJ 2009 The Journal of biological chemistry
Long patch base excision repair in mammalian mitochondrial genomes. Longley MJ 2008 The Journal of biological chemistry
DNA polymerase gamma in mitochondrial DNA replication and repair. Longley MJ 2006 Chem Rev
Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphismin mitochondrial disorders. Longley MJ 2006 Hum Mol Genet
Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia. Longley MJ 2006 Am J Hum Genet
Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome. Longley MJ 2005 DNA repair
Consequences of mutations in human DNA polymerase gamma. Longley MJ 2005 Gene
The common A467T mutation in the human mitochondrial DNA polymerase (POLG) compromises catalytic efficiency and interaction with the accessory subunit. Longley MJ 2005 The Journal of biological chemistry
Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia. Longley MJ 2004 Nature structural & molecular biology
DNA polymerase gamma in mitochondrial DNA replication and repair. Longley MJ 2003 ScientificWorldJournal
Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs. Longley MJ 2003 Journal of molecular biology
Mutations in DNA polymerase gamma cause error prone DNA synthesis in human mitochondrial disorders. Longley MJ 2003 Acta Biochim Pol
Purification, separation, and identification of the human mtDNA polymerase with and without its accessory subunit. Longley MJ 2002 Methods in molecular biology (Clifton, N.J.)
Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis. Longley MJ 2002 The Journal of biological chemistry
The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit. Longley MJ 2001 The Journal of biological chemistry
The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance. Longley MJ 1999 The Journal of biological chemistry
Characterization of the native and recombinant catalytic subunit of human DNA polymerase gamma: identification of residues critical for exonuclease activity and dideoxynucleotide sensitivity. Longley MJ 1998 Biochemistry
Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro. Longley MJ 1998 Proceedings of the National Academy of Sciences of the United States of America
DNA polymerase delta is required for human mismatch repair in vitro. Longley MJ 1997 The Journal of biological chemistry
Properties of the 3' to 5' exonuclease associated with porcine liver DNA polymerase gamma. Substrate specificity, product analysis, inhibition, and kinetics of terminal excision. Longley MJ 1991 The Journal of biological chemistry
Characterization of the 5' to 3' exonuclease associated with Thermus aquaticus DNA polymerase. Longley MJ 1990 Nucleic acids research
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