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Chamberlain PP

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Publications:

Title Authors Year Journal
Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors. Chamberlain PP 2008 J Med Chem
Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases. Chamberlain PP 2007 J Med Chem
Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138. Chamberlain PP 2006 FEBS J
Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors. Chamberlain PP 2004 Journal of molecular biology
Cloning, expression, purification, and crystallisation of HIV-2 reverse transcriptase. Chamberlain PP 2003 Protein expression and purification
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215. Chamberlain PP 2002 J Virol
Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors. Chamberlain PP 2002 Proceedings of the National Academy of Sciences of the United States of America

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