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Clark PK

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Publications:

Title Authors Year Journal
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. Clark PK 2004 J Med Chem
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir. Clark PK 2004 Nature structural & molecular biology
Cross-linking of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase to template-primer. Clark PK 2001 Journal of virology
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. Clark PK 1996 Journal of molecular biology
Crystallization of human immunodeficiency virus type 1 reverse transcriptase with and without nucleic acid substrates, inhibitors, and an antibody Fab fragment. Clark PK 1995 Methods in enzymology
Mutational analysis of the fingers and palm subdomains of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase. Clark PK 1994 Journal of molecular biology
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Clark PK 1993 Proceedings of the National Academy of Sciences of the United States of America
Structure of HIV-1 reverse transcriptase/DNA complex at 7 A resolution showing active site locations. Clark PK 1992 Nature
Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract x-rays to 3.5-A resolution. Clark PK 1991 Proceedings of the National Academy of Sciences of the United States of America

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