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Frenkel YV

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Publications:

Title Authors Year Journal
Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening. Frenkel YV 2013 Journal of medicinal chemistry
Structural basis of HIV-1 resistance to AZT by excision. Frenkel YV 2010 Nature structural & molecular biology
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations. Frenkel YV 2008 Proceedings of the National Academy of Sciences of the United States of America
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine). Frenkel YV 2005 J Med Chem
Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability. Frenkel YV 2005 J Med Chem
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