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Chan SS

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Publications:

Title Authors Year Journal
Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination. Chan SS Environmental and molecular mutagenesis
Mitochondrial disorders of DNA polymerase γ dysfunction: from anatomic to molecular pathology diagnosis. Chan SS 2011 Archives of pathology & laboratory medicine
Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication. Chan SS 2009 The Journal of biological chemistry
DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations. Chan SS 2009 Biochimica et biophysica acta
Functional analysis of mutant mitochondrial DNA polymerase proteins involved in human disease. Chan SS 2009 Methods in molecular biology (Clifton, N.J.)
Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma. Chan SS 2007 Laboratory investigation; a journal of technical methods and pathology
Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphismin mitochondrial disorders. Chan SS 2006 Hum Mol Genet
Molecular diagnosis of Alpers syndrome. Chan SS 2006 Journal of hepatology
Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome. Chan SS 2005 DNA repair
The common A467T mutation in the human mitochondrial DNA polymerase (POLG) compromises catalytic efficiency and interaction with the accessory subunit. Chan SS 2005 The Journal of biological chemistry
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