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Buckheit RW

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Publications:

Title Authors Year Journal
Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase. Buckheit RW 2009 J Med Chem
Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Buckheit RW 2009 European journal of medicinal chemistry
Inhibition of tubulin polymerization by select alkenyldiarylmethanes. Buckheit RW 2008 Bioorganic & medicinal chemistry letters
Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors. Buckheit RW 2008 Bioorganic & medicinal chemistry letters
Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability. Buckheit RW 2007 Journal of medicinal chemistry
Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems. Buckheit RW 2007 Journal of medicinal chemistry
Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme. Buckheit RW 2007 Journal of medicinal chemistry
Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings. Buckheit RW 2006 Bioorganic & medicinal chemistry
Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents. Buckheit RW 2006 Journal of medicinal chemistry
Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors. Buckheit RW 2005 Journal of medicinal chemistry
A novel mechanism for inhibition of HIV-1 reverse transcriptase. Buckheit RW 2002 Bioorganic chemistry
Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain. Buckheit RW 2000 Bioorganic & medicinal chemistry
New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors. Buckheit RW 1998 Journal of medicinal chemistry
Highly potent oxathiin carboxanilide derivatives with efficacy against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus isolates. Buckheit RW 1997 Antimicrobial agents and chemotherapy
Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles. Buckheit RW 1997 Journal of medicinal chemistry
Molecular modeling of HIV-1 reverse transcriptase drug-resistant mutant strains: implications for the mechanism of polymerase action. Buckheit RW 1997 Protein engineering
Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase. Buckheit RW 1995 Virology
Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilide. Buckheit RW 1995 Antimicrobial agents and chemotherapy
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