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Jaeger J

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Publications:

Title Authors Year Journal
Structural changes in the hydrophobic hinge region adversely affect the activity and fidelity of the I260Q mutator of DNA polymerase ß Jaeger J 2013 Biochemistry
Unfavorable electrostatic and steric interactions in DNA polymerase β E295K mutant interfere with the enzyme's pathway. Jaeger J 2012 Journal of the American Chemical Society
The E288K Colon Tumor Variant of DNA Polymerase Beta Is a Sequence Specific Mutator. Jaeger J 2012 Biochemistry
A Triad Interaction in the Fingers Subdomain of DNA Polymerase Beta Controls Polymerase Activity Jaeger J 2011 Journal of the American Chemical Society
A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity. Jaeger J 2011 Journal of the American Chemical Society
Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Jaeger J 2010 Biochemistry
Loop II of DNA polymerase beta is important for discrimination during substrate binding. Jaeger J 2009 DNA repair
The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient. Jaeger J 2008 Nucleic acids research
The I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates. Jaeger J 2008 Biochemistry
The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding. Jaeger J 2008 Biochemistry
Loop II of DNA polymerase beta is important for polymerization activity and fidelity. Jaeger J 2007 Nucleic acids research
The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry. Jaeger J 2005 The Journal of biological chemistry
The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor. Jaeger J 1998 The EMBO journal
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