Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta.

Abstract:

DNA polymerase beta (pol beta) is the key gap-filling polymerase in ...

Polymerases:

Topics:

Mutational Analysis, Kinetic Parameters, Fidelity, Nucleotide Incorporation

Status:

new topics/pols set partial results complete validated

Results:

Polymerase Reference Property Result Context
Human Pol beta Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Kd 9uM Reaction: Misincorporation; Substrate: dCTP; Technique: Single Turnover (G template)
Human Pol beta Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Kd 590uM Reaction: Misincorporation; Substrate: dTTP; Technique: Single Turnover (G template)
Human Pol beta Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Kd 72uM Reaction: Misincorporation; Substrate: dATP; Technique: Single Turnover (G template)
Human Pol beta Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Kd 120uM Reaction: Misincorporation; Substrate: dGTP; Technique: Single Turnover (G template)

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