Rat Pol beta
Welcome to the Polymerase Page
This page presents all the information in Polbase for Rat Pol beta.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
Selected Properties for Rat Pol beta: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| Yes (1) | no data | 3.6e-02 errors/bp (1) | 2.2e-02 errors/bp (1) | 6.4e-02 errors/bp (1) |
- References (24)
- Structures (20)
- Sequences (1)
- Mutants (1)...
- Formulations (0)
- Polymerase Lots (0)
- External links
| Year | Authors | Title | Results by property |
|---|---|---|---|
| 2013 | Yoshiyuki Mizushina, Isoko Kuriyama, Tatsuo Nakahara, Yoshihito Kawashima, Hiromi Yoshida | Inhibitory effects of α-mangostin on ... | |
| 2013 | Chelsea L Gridley, Sneha Rangarajan, Susan J Firbank, Shibani Dalal, Joann B Sweasy, Joachim Jaeger | Structural changes in the hydrophobic... | |
| 2012 | V N Vyjayanti, Umakanta Swain, Kalluri Subba Rao | Age-related decline in DNA polymerase... | |
| 2011 | Joann B Sweasy, Joachim Jaeger, Drew L Murphy | A Triad Interaction in the Fingers Su... | |
| 2010 | Ken Hirano, Yuichiro Yoshida, Tomomi Ishido, Yukihisa Wada, Naoji Moriya, Naoshi Yamazaki, Yoshiyuki Mizushina, Yoshinobu Baba, Mitsuru Ishikawa | Consecutive incorporation of fluoroph... | |
| 2010 | Matthew J Cuneo, Robert E London | Oxidation state of the XRCC1 N-termin... | |
| 2008 | Kuo-Hsiang Tang, Marc Niebuhr, Chang-Shung Tung, Hsiu-Chien Chan, Chia-Cheng Chou, Ming-Daw Tsai | Mismatched dNTP incorporation by DNA ... | |
| 2007 | Melanie F Brown, Jeffrey A Stuart | Correlation of mitochondrial superoxi... | |
| 2007 | George C Lin, Joachim Jaeger, Joann B Sweasy | Loop II of DNA polymerase beta is imp... | |
| 2007 | Tieming Lang, Shibani Dalal, Anna K Chikova, Daniel Dimaio, Joann B Sweasy | The E295K DNA polymerase beta gastric... | |
| 2002 | Yoshiyuki Mizushina, Shinji Kamisuki, Nobuyuki Kasai, Tomomi Ishidoh, Noriko Shimazaki, Masaharu Takemura, Hitomi Asahara, Stuart Linn, Shonen Yoshida, Osamu Koiwai, Fumio Sugawara, Hiromi Yoshida, Kengo Sakaguchi | Petasiphenol: a DNA polymerase lambda... | |
| 2001 | J W Arndt, W Gong, Xuejun Zhong, Alexander K Showalter, Jianhua Liu, Christopher A Dunlap, Z Lin, C Paxson, Ming-Daw Tsai, M K Chan | Insight into the catalytic mechanism ... | |
| 2000 | Mark W Maciejewski, D Liu, Rajendra Prasad, Samuel H Wilson, Gregory P Mullen | Backbone dynamics and refined solutio... | |
| 2000 | Igor V Shevelev, N V Belyakova, T P Kravetskaya, V M Krutyakov | Autonomous 3'-->5' exonucleases can p... | 3-5' exo,All properties |
| 1999 | Y Timsit | DNA structure and polymerase fidelity. | |
| 1997 | J Ahn, B G Werneburg, Ming-Daw Tsai | DNA polymerase beta: structure-fideli... | |
| 1997 | V S Kraynov, B G Werneburg, Xuejun Zhong, H Lee, J Ahn, Ming-Daw Tsai | DNA polymerase beta: analysis of the ... | |
| 1996 | D Liu, Rajendra Prasad, Samuel H Wilson, Eugene F DeRose, Gregory P Mullen | Three-dimensional solution structure ... | |
| 1996 | H Pelletier, M R Sawaya | Characterization of the metal ion bin... | |
| 1994 | M R Sawaya, H Pelletier, A Kumar, Samuel H Wilson, J Kraut | Crystal structure of rat DNA polymera... | |
| 1987 | Akio Matsukage, K Nishikawa, T Ooi, Y Seto, Masamitsu Yamaguchi | Homology between mammalian DNA polyme... | |
| 1985 | Thomas A Kunkel | The mutational specificity of DNA pol... | Cloned or native,Full length or truncated,Frameshift Error Rate,Nucleotide Substitution Rate,Overall Error Rate,All properties |
| 1973 | A M de Recondo, J A Lepesant, O Fichot, L Grasset, J M Rossignol, M Cazillis | Synthetic template specificity of a d... | |
| 1971 | H Berger, R C Huang, J L Irvin | Purification and characterization of ... |
Predicted Structure Model
This AlphaFold DB model is predicted and not an experimentally determined structure. View AlphaFold DB entry Download predicted model (.pdb)
Confidence legend (pLDDT)
AlphaFold DB colors residues by predicted confidence. Use high-confidence regions for structural context and treat low-confidence regions cautiously.
- Very high (pLDDT > 90) Backbone and side chains are usually reliable.
- Confident (pLDDT 70-90) Overall fold is usually reliable, but some local detail may shift.
- Low (pLDDT 50-70) Use with caution; this region may be flexible or uncertain.
- Very low (pLDDT < 50) Often disordered or not confidently placed.
| Name | 3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| Rat Pol beta I260Q |
Protein information: Uniprot P06766 search for Rat Pol beta at UniProt
Sequence information: NCBI nucleotides European nucleotide archive
Predicted structure: AlphaFold DB entry AF-P06766-F1