HIV RT Y181I

From HIV
show help

Welcome to the Polymerase Page

This page presents all the information in Polbase for HIV RT Y181I.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

Mutant of: HIV RT (Y181I)

HIV RT Y181I is a family RT enzyme from HIV. "From the Los Alamos National Labs HIV Mutant database (now offline):|id:506|codon:TGT>ATT|drugs:BHAP U-88204E|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Appeared after treatment of Y181C-mutated virus with BHAP; high-level resistance to BHAP "From the Los Alamos National Labs HIV Mutant database (now offline):|id:508|codon:TAT>ATT|drugs:I-EBU From the Los Alamos National Labs HIV Mutant database (now offline):|id:509|codon:TAT>ATT|drugs:TMC125|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Clinical isolate with this mutation is associated with decreased phenotypic susceptibility

Selected Properties for HIV RT Y181I:

 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
1996 Jan Balzarini, H Pelemans, María-Jesús Pérez-Pérez, Ana San-Félix, María-José Camarasa, Erik De Clercq, Anna Karlsson Marked inhibitory activity of non-nuc...
1994 Jan Balzarini, Anna Karlsson, V V Sardana, E A Emini, María-José Camarasa, Erik De Clercq Human immunodeficiency virus 1 (HIV-1...

Version:20241218

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.