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Welcome to the Polymerase Page

This page presents all the information in Polbase for HIV RT Y181I.


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Mutant of: HIV RT (Y181I)

HIV RT Y181I is a family RT enzyme from HIV. "From the Los Alamos National Labs HIV Mutant database (now offline):|id:506|codon:TGT>ATT|drugs:BHAP U-88204E|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Appeared after treatment of Y181C-mutated virus with BHAP; high-level resistance to BHAP "From the Los Alamos National Labs HIV Mutant database (now offline):|id:508|codon:TAT>ATT|drugs:I-EBU From the Los Alamos National Labs HIV Mutant database (now offline):|id:509|codon:TAT>ATT|drugs:TMC125|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Clinical isolate with this mutation is associated with decreased phenotypic susceptibility

Selected Properties for HIV RT Y181I:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
1996 Jan Balzarini, H Pelemans, María-Jesús Pérez-Pérez, Ana San-Félix, María-José Camarasa, Erik De Clercq, Anna Karlsson Marked inhibitory activity of non-nuc...
1994 Jan Balzarini, Anna Karlsson, V V Sardana, E A Emini, María-José Camarasa, Erik De Clercq Human immunodeficiency virus 1 (HIV-1...

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