MMuLV RT

From Moloney Murine Leukemia Virus (aliases:MLV, Moloney Murine Leukemia Virus Reverse Transcriptase, M-MuLV RT)
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Welcome to the Polymerase Page

This page presents all the information in Polbase for MMuLV RT.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

Missing mutants?
MMuLV RT is a family RT enzyme from Moloney Murine Leukemia Virus.

Selected Properties for MMuLV RT:

 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
No (1) no data no data no data no data
Year Authors Title Results by property
2009 LaTeca S Glass, Binh Nguyen, Kristie D Goodwin, Christophe Dardonville, W David Wilson, Eric C Long, Millie M Georgiadis Crystal structure of a trypanocidal 4...
2008 Kristie D Goodwin, Mark A Lewis, Eric C Long, Millie M Georgiadis Crystal structure of DNA-bound Co(III...
2006 Kristie D Goodwin, Mark A Lewis, Farial A Tanious, Richard R Tidwell, W David Wilson, Millie M Georgiadis, Eric C Long A high-throughput, high-resolution st...
2006 Sherwin P Montaño, Marie L Coté, Monica J Roth, Millie M Georgiadis Crystal structures of oligonucleotide...
2005 Darwin J Operario, Holly M Reynolds, Baek Kim Comparison of DNA polymerase activiti... Molecular Weight,All properties
2005 Kristie D Goodwin, Eric C Long, Millie M Georgiadis A host-guest approach for determining...
2004 Debanu Das, Millie M Georgiadis The crystal structure of the monomeri... RT,All properties
2000 S Najmudin, Marie L Coté, D Sun, S Yohannan, Sherwin P Montano, J Gu, Millie M Georgiadis Crystal structures of an N-terminal f...
1994 S H Whiting, J J Champoux Strand displacement synthesis capabil... Nick Extension,Strand Displacement,All properties
1992 J J DeStefano, R G Buiser, L M Mallaber, P J Fay, Robert A Bambara Parameters that influence processive ... RT,Cloned or native,Full length or truncated,Specific Activity,RNase H,All properties
1989 J D Roberts, Bradley D Preston, L A Johnston, A Soni, Lawrence A Loeb, Thomas A Kunkel Fidelity of two retroviral reverse tr... RT,3-5' exo,Molecular Weight,RNase H,All properties
1985 M J Roth, N Tanese, S P Goff Purification and characterization of ...
1975 I M Verma Studies on reverse transcriptase of R... Molecular Weight,RNase H,All properties
Protein sequence:

Predicted Structure Model

Predicted model AlphaFold DB Not experimentally determined

This AlphaFold DB model is predicted and not an experimentally determined structure. View AlphaFold DB entry Download predicted model (.pdb)

Confidence legend (pLDDT)

AlphaFold DB colors residues by predicted confidence. Use high-confidence regions for structural context and treat low-confidence regions cautiously.

  • Very high (pLDDT > 90) Backbone and side chains are usually reliable.
  • Confident (pLDDT 70-90) Overall fold is usually reliable, but some local detail may shift.
  • Low (pLDDT 50-70) Use with caution; this region may be flexible or uncertain.
  • Very low (pLDDT < 50) Often disordered or not confidently placed.
3FSI
2R2S
2R2U
2R2T
2R2R
2FVS
2FVR
2FVQ
2FVP
2FJW
2FJX
2FJV
1ZTW
1ZTT
1RW3
1QAJ
1QAI
1D0E
Name 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
MMuLV RT N term R116A
MMuLV RT N term

Version:20260603

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