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Welcome to the Polymerase Page

This page presents all the information in Polbase for HIV RT E138K.


At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.


If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

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All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

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Mutant of: HIV RT (E138K)

HIV RT E138K is a family RT enzyme from HIV. "From the Los Alamos National Labs HIV Mutant database (now offline):|id:452|codon:GAG>AAG|drugs:I-EBU From the Los Alamos National Labs HIV Mutant database (now offline):|id:453|codon:GAG>AAG|drugs:TIBO R82913|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Found in combination with L100I From the Los Alamos National Labs HIV Mutant database (now offline):|id:454|codon:GAG>AAG|drugs:TSAO|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:E138A (GAG to GCG) in TSAO-naive patients confers TSAO viral resistance "From the Los Alamos National Labs HIV Mutant database (now offline):|id:455|codon:GAG>AAG|drugs:UC-82|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Activity of UC-82 versus L100I "From the Los Alamos National Labs HIV Mutant database (now offline):|id:456|codon:GAG>AAG|drugs:UC-84

Selected Properties for HIV RT E138K:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
2013 Matthew McCallum, Maureen Oliveira, Ruxandra-Ilinca Ibanescu, Victor G Kramer, Daniela D Moisi, Eugene L Asahchop, Bluma G Brenner, Richard Harrigan, Hongtao Xu, Mark A. Wainberg Basis for the Early and Preferential ...
2013 Hong-Tao Xu, Susan P Colby-Germinario, Eugene L Asahchop, Maureen Oliveira, Matthew McCallum, Susan M Schader, Yingshan Han, Yudong Quan, Stefan G Sarafianos, Mark A. Wainberg The Effect of Mutations at Position E...
2012 Kamalendra Singh, Bruno Marchand, Devendra K Rai, Bechan Sharma, Eleftherios Michailidis, Emily M Ryan, Kayla B Matzek, Maxwell D Leslie, Ariel N Hagedorn, Zhongjie Li, Pieter R Norden, Atsuko Hachiya, Michael A. Parniak, Hong-Tao Xu, Mark A. Wainberg, Stefan G Sarafianos Biochemical Mechanism of HIV-1 Resist...
2006 Jingshan Ren, Charles E Nichols, Anna Stamp, Phillip P Chamberlain, Robert G Ferris, Kurt L Weaver, Steven A Short, David K Stammers Structural insights into mechanisms o... RT,Associated condition,All properties
1996 Jan Balzarini, H Pelemans, María-Jesús Pérez-Pérez, Ana San-Félix, María-José Camarasa, Erik De Clercq, Anna Karlsson Marked inhibitory activity of non-nuc...
1996 Jan Balzarini, W G Brouwer, D C Dao, E M Osika, Erik De Clercq Identification of novel thiocarboxani...
1996 Jan Balzarini, H Pelemans, Stefano Aquaro, CF Perno, Myriam Witvrouw, Dominique Schols, Erik De Clercq, Anna Karlsson Highly favorable antiviral activity a...
1995 Jan Balzarini, María-Jesús Pérez-Pérez, S Vélazquez, Ana San-Félix, María-José Camarasa, Erik De Clercq, Anna Karlsson Suppression of the breakthrough of hu...
1993 Jan Balzarini, Sonsoles Velazquez, A San-Felix, Anna Karlsson, M J Perez-Perez, María-José Camarasa, Erik De Clercq Human immunodeficiency virus type 1-s...
1993 Jan Balzarini, Anna Karlsson, María-Jesús Pérez-Pérez, L Vrang, J Walbers, Haijiang Zhang, Bo Oberg, A-M Vandamme, María-José Camarasa, Erik De Clercq HIV-1-specific reverse transcriptase ...
1993 Jan Balzarini, Anna Karlsson, A-M Vandamme, María-Jesús Pérez-Pérez, Haijiang Zhang, L Vrang, Bo Oberg, K Bäckbro, Torsten Unge, Ana San-Félix Human immunodeficiency virus type 1 (...

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