HIV RT V106A

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This page presents all the information in Polbase for HIV RT V106A.

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Mutant of: HIV RT (V106A)

HIV RT V106A is a family RT enzyme from HIV. From the Los Alamos National Labs HIV Mutant database (now offline):|id:417|codon:GTA>GCA|drugs:ADAMII|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:7.13-fold. Tested against a site-directed mutant. From the Los Alamos National Labs HIV Mutant database (now offline):|id:418|codon:GTA>GCA|drugs:BHAP U-88204E|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:7.13-fold. Tested against a site-directed mutant. "From the Los Alamos National Labs HIV Mutant database (now offline):|id:419|codon:GTA>GCA|drugs:BI-RG-587 From the Los Alamos National Labs HIV Mutant database (now offline):|id:420|codon:GTA>GCA|drugs:E-EBU-dM|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:7.13-fold. Tested against a site-directed mutant. From the Los Alamos National Labs HIV Mutant database (now offline):|id:421|codon:GTA>GCA|drugs:S-1153|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:V106A + F227L: 387-fold "From the Los Alamos National Labs HIV Mutant database (now offline):|id:422|codon:GTA>GCA|drugs:S-2720 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:423|codon:GTA>GCA|drugs:TIBO R82913|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:P225H follows V106A. Also seen with L101I and Y181C. Double and triple mutants highly resistant to other NNRTI's "From the Los Alamos National Labs HIV Mutant database (now offline):|id:424|codon:GTA>GCA|drugs:UC-69 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:425|codon:GTA>GCA|drugs:UC-82|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Activity of UC-82 versus L100I

Selected Properties for HIV RT V106A:

3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
Unknown
2004 Jingshan Ren, Charles E Nichols, Phillip P Chamberlain, Kurt L Weaver, Steven A Short, David K Stammers Ren J2004
1998 Tsuyoshi Fujiwara, Akira Sato, M el-Farrash, S Miki, K Abe, Y Isaka, M Kodama, Y Wu, L B Chen, H Harada, H Sugimoto, Masami Hatanaka, Y Hinuma Fujiwara T1998
1998 Mark Cushman, A Casimiro-Garcia, E Hejchman, J A Ruell, M Huang, C A Schaeffer, K Williamson, W G Rice, Robert W Buckheit Cushman M1998
1997 H Pelemans, Robert Esnouf, A Dunkler, Michael A. Parniak, A-M Vandamme, Anna Karlsson, Erik De Clercq, Jörg-Peter Kleim, Jan Balzarini Pelemans H1997
1996 Jan Balzarini, H Pelemans, Stefano Aquaro, CF Perno, Myriam Witvrouw, Dominique Schols, Erik De Clercq, Anna Karlsson Balzarini J1996
1996 Jan Balzarini, W G Brouwer, D C Dao, E M Osika, Erik De Clercq Balzarini J1996
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Buckheit RW1995
1994 Douglas D Richman, D Havlir, J Corbeil, D Looney, C Ignacio, S A Spector, J Sullivan, S Cheeseman, K Barringer, D Pauletti Richman DD1994
1993 Jan Balzarini, Anna Karlsson, Erik De Clercq Balzarini J1993
1992 M B Vasudevachari, C Battista, H C Lane, M C Psallidopoulos, B Zhao, J Cook, J R Palmer, D L Romero, W G Tarpley, N P Salzman Vasudevachari MB1992
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