HIV RT V106A

From HIV
show help

Welcome to the Polymerase Page

This page presents all the information in Polbase for HIV RT V106A.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

Mutant of: HIV RT (V106A)

HIV RT V106A is a family RT enzyme from HIV. From the Los Alamos National Labs HIV Mutant database (now offline):|id:417|codon:GTA>GCA|drugs:ADAMII|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:7.13-fold. Tested against a site-directed mutant. From the Los Alamos National Labs HIV Mutant database (now offline):|id:418|codon:GTA>GCA|drugs:BHAP U-88204E|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:7.13-fold. Tested against a site-directed mutant. "From the Los Alamos National Labs HIV Mutant database (now offline):|id:419|codon:GTA>GCA|drugs:BI-RG-587 From the Los Alamos National Labs HIV Mutant database (now offline):|id:420|codon:GTA>GCA|drugs:E-EBU-dM|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:7.13-fold. Tested against a site-directed mutant. From the Los Alamos National Labs HIV Mutant database (now offline):|id:421|codon:GTA>GCA|drugs:S-1153|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:V106A + F227L: 387-fold "From the Los Alamos National Labs HIV Mutant database (now offline):|id:422|codon:GTA>GCA|drugs:S-2720 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:423|codon:GTA>GCA|drugs:TIBO R82913|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:P225H follows V106A. Also seen with L101I and Y181C. Double and triple mutants highly resistant to other NNRTI's "From the Los Alamos National Labs HIV Mutant database (now offline):|id:424|codon:GTA>GCA|drugs:UC-69 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:425|codon:GTA>GCA|drugs:UC-82|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Activity of UC-82 versus L100I

Selected Properties for HIV RT V106A:

 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
2004 Jingshan Ren, Charles E Nichols, Phillip P Chamberlain, Kurt L Weaver, Steven A Short, David K Stammers Crystal structures of HIV-1 reverse t...
1998 Tsuyoshi Fujiwara, Akira Sato, M el-Farrash, S Miki, K Abe, Y Isaka, M Kodama, Y Wu, L B Chen, H Harada, H Sugimoto, Masami Hatanaka, Y Hinuma S-1153 inhibits replication of known ...
1998 Mark Cushman, A Casimiro-Garcia, E Hejchman, J A Ruell, M Huang, C A Schaeffer, K Williamson, W G Rice, Robert W Buckheit New alkenyldiarylmethanes with enhanc...
1997 H Pelemans, Robert Esnouf, A Dunkler, Michael A. Parniak, A-M Vandamme, Anna Karlsson, Erik De Clercq, Jörg-Peter Kleim, Jan Balzarini Characteristics of the Pro225His muta...
1996 Jan Balzarini, H Pelemans, Stefano Aquaro, CF Perno, Myriam Witvrouw, Dominique Schols, Erik De Clercq, Anna Karlsson Highly favorable antiviral activity a...
1996 Jan Balzarini, W G Brouwer, D C Dao, E M Osika, Erik De Clercq Identification of novel thiocarboxani...
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Structure-activity and cross-resistan...
1994 Douglas D Richman, D Havlir, J Corbeil, D Looney, C Ignacio, S A Spector, J Sullivan, S Cheeseman, K Barringer, D Pauletti Nevirapine resistance mutations of hu...
1993 Jan Balzarini, Anna Karlsson, Erik De Clercq Human immunodeficiency virus type 1 d...
1992 M B Vasudevachari, C Battista, H C Lane, M C Psallidopoulos, B Zhao, J Cook, J R Palmer, D L Romero, W G Tarpley, N P Salzman Prevention of the spread of HIV-1 inf...

Version:20240424

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.