HIV RT M184V

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This page presents all the information in Polbase for HIV RT M184V.

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Mutant of: HIV RT (M184V)

HIV RT M184V is a family RT enzyme from HIV. "From the Los Alamos National Labs HIV Mutant database (now offline):|id:520|codon:ATG>GTG|drugs:1592U89 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:521|codon:ATG>GTG|drugs:3TC "From the Los Alamos National Labs HIV Mutant database (now offline):|id:522|codon:ATG>GTG|drugs:dOTC "From the Los Alamos National Labs HIV Mutant database (now offline):|id:523|codon:ATG>GTG|drugs:ddC "From the Los Alamos National Labs HIV Mutant database (now offline):|id:524|codon:ATG>GTG|drugs:ddI From the Los Alamos National Labs HIV Mutant database (now offline):|id:525|codon:ATG>GTG|drugs:(-)dOTC|class:Nucleoside RT Inhibitor (NRTI)|notes:Selected in 15-20 passages From the Los Alamos National Labs HIV Mutant database (now offline):|id:526|codon:ATG>GTG|drugs:(+)dOTC|class:Nucleoside RT Inhibitor (NRTI)|notes:6-7-fold resistance From the Los Alamos National Labs HIV Mutant database (now offline):|id:527|codon:ATG>GTG|drugs:(-)dOTFC|class:Nucleoside RT Inhibitor (NRTI)|notes:high level resistance From the Los Alamos National Labs HIV Mutant database (now offline):|id:528|codon:ATG>GTG|drugs:(+)dOTFC|class:Nucleoside RT Inhibitor (NRTI)|notes:high level resistance "From the Los Alamos National Labs HIV Mutant database (now offline):|id:529|codon:ATG>GTG|drugs:(-)-FTC From the Los Alamos National Labs HIV Mutant database (now offline):|id:530|codon:ATG>GTG|drugs:L-FddC|class:Nucleoside RT Inhibitor (NRTI)|notes:>100-fold resistant to 3TC-resistant virus From the Los Alamos National Labs HIV Mutant database (now offline):|id:984|codon:TAT>TTT|drugs:VRX-329747|class:RT inhibitor|notes:This mutation also acts synergistically with K103N and Y181C to confer higher levels of resistance to DLV and EFV than seen with either of these mutations alone From the Los Alamos National Labs HIV Mutant database (now offline):|id:991|codon:TAT>TTT|drugs:VRX-413638|class:RT inhibitor|notes:This mutation also acts synergistically with K103N and Y181C to confer higher levels of resistance to DLV and EFV than seen with either of these mutations alone

Selected Properties for HIV RT M184V:

 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
2007 Paul L Boyer, John G Julias, Zandrea Ambrose, Maqbool A Siddiqui, Victor E Marquez, Stephen H Hughes The nucleoside analogs 4'C-methyl thy...
2006 Zhijun Zhang, Michelle Walker, Wen Xu, Jae Hoon Shim, Jean-Luc Girardet, Robert K Hamatake, Zhi Hong Novel nonnucleoside inhibitors that s...
2006 Zhijun Zhang, Michelle Walker, Wen Xu, Jae Hoon Shim, Jean-Luc Girardet, Robert K Hamatake, Zhi Hong Novel nonnucleoside inhibitors that s...
2002 Phillip P Chamberlain, Jingshan Ren, Charles E Nichols, L Douglas, Johan Lennerstrand, Brendan A Larder, David I Stuart, David K Stammers Crystal structures of Zidovudine- or ...
2002 Janina Cramer, Michael Strerath, Andreas Marx, Tobias Restle Exploring the effects of active site ... RT,Associated condition,All properties
2000 N Richard, H Salomon, R Rando, T Mansour, T L Bowlin, Mark A. Wainberg Selection and characterization of hum...
2000 D L Taylor, P S Ahmed, A S Tyms, L J Wood, L A Kelly, P Chambers, J Clarke, J Bedard, T L Bowlin, R F Rando Drug resistance and drug combination ...
2000 N Richard, H Salomon, R Rando, T Mansour, T L Bowlin, Mark A. Wainberg Selection and characterization of hum...
1999 N Richar, Yudong Quan, H Salomon, M Hsu, J Bedard, P Richard Harrigan, R Rando, T Mansour, T L Bowlin, Mark A. Wainberg Selection and characterization of HIV...
1997 M Tisdale, T Alnadaf, D Cousens Combination of mutations in human imm...
1994 G Gosselin, Raymond F Schinazi, J P Sommadossi, C Mathé, M C Bergogne, A M Aubertin, A Kirn, J L Imbach Anti-human immunodeficiency virus act...
1993 Raymond F Schinazi, R M Lloyd, M H Nguyen, D L Cannon, A McMillan, N Ilksoy, Chung K Chu, Dennis C Liotta, Holly Z Bazmi, John W Mellors Characterization of human immunodefic...
1993 Q Gao, Z Gu, Michael A. Parniak, J Cameron, Nick Cammack, C Boucher, Mark A. Wainberg The same mutation that encodes low-le...
1993 M Tisdale, S D Kemp, N R Parry, Brendan A Larder Rapid in vitro selection of human imm...
1992 Q Gao, Z X Gu, Michael A. Parniak, X G Li, Mark A. Wainberg In vitro selection of variants of hum...
1992 Z Gu, Q Gao, Xincang Li, Michael A. Parniak, Mark A. Wainberg Novel mutation in the human immunodef...
1992 Z Gu, Q Gao, Xincang Li, Michael A. Parniak, Mark A. Wainberg Novel mutation in the human immunodef...

Version:20241218

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