hTERT

From H. sapiens (aliases:Human telomerase reverse transcriptase)
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Welcome to the Polymerase Page

This page presents all the information in Polbase for hTERT.

Mutants:

At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.

Structures/Sequence:

If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.

External links:

Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.

References:

All references that refer to this Polymerase are listed with their topics and paper's title in the References table.

Results:

All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.

Help icons:

The show help symbol in the upper-right corner of the page links to this help text. The question mark icon is used everywhere to indicate that help is available.

Missing mutants?
hTERT is a family RT enzyme from H. sapiens.

Selected Properties for hTERT:

 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
2013 Donghong Zhang, Xuemei Wen, Wei Wu, Ermu Xu, Yujuan Zhang, Wei Cui Homocysteine-related hTERT DNA demeth...
2013 Jing Zuo, Da-Hu Wang, Yu-Jun Zhang, Liang Liu, Feng-Ling Liu, Wei Liu Expression and mechanism of PinX1 and...
2013 Zhenhong Zhao, Cong Li, Lixin Yang, Xiaobo Zhang, Xueying Zhao, Xiao Song, Xiaoying Li, Jiucun Wang, Ji Qian, Yajun Yang, Li Jin, Hongyan Chen, Daru Lu Significant association of 5p15.33 (T...
2013 Xuejiao Tian, Saiyang Zhang, Hong-Min Liu, Yan-Bing Zhang, Christopher A Blair, Dan Mercola, Paolo Sassone-Corsi, Xiaolin Zi Histone Lysine-Specific Methyltransfe...
2013 L P Lv, Y L Kong, F Yan, P Ma, X P Zhou, Y Y Zhang, D Q Wen, X L Yu, H Y Zhang, H Zhou, J B Xu Hepatocytes transduced with human TER...
2011 Craig Nicholls, He Li, Jian-Qiu Wang, Jun-Ping Liu Molecular regulation of telomerase ac...
2011 M Borssen, I Cullman, U Noren-Nystrom, C Sundstrom, A Porwit, E Forestier, G Roos hTERT promoter methylation and telome...
2011 Yi Yang, Jing-Li Liu, Chao Qin, Jin-Pin Li, Xiao-Ling Wang, Zhao-Xia Zhang, Linqi Zhang [Effects of cerebellar fastigial nucl...
2011 Yang Zhang, Hongxing Zhang, Yun Zhai, Zhifu Wang, Fuchao Ma, Hongxue Wang, Peiyao Li, Ying Zhang, Lixia Yu, Ying Cui, Fuchu He, Gangqiao Zhou A functional tandem-repeats polymorph...
2007 William C Drosopoulos, Vinayaka R Prasad The active site residue Valine 867 in... RT,All properties
2006 Steven A Jacobs, Elaine R Podell, Thomas R Cech Crystal structure of the essential N-... RT,All properties
2002 Colleen Kelleher, M Teresa Teixeira, Klaus Förstemann, Joachim Lingner Telomerase: biochemical consideration...
2000 K Yamada, T Yajima, A Yagihashi, D Kobayashi, Y Koyanagi, K Asanuma, Masami Yamada, R Moriai, H Kameshima, N Watanabe Role of human telomerase reverse tran...
Protein sequence:

Predicted Structure Model

Predicted model AlphaFold DB Not experimentally determined

This AlphaFold DB model is predicted and not an experimentally determined structure. View AlphaFold DB entry Download predicted model (.pdb)

Confidence legend (pLDDT)

AlphaFold DB colors residues by predicted confidence. Use high-confidence regions for structural context and treat low-confidence regions cautiously.

  • Very high (pLDDT > 90) Backbone and side chains are usually reliable.
  • Confident (pLDDT 70-90) Overall fold is usually reliable, but some local detail may shift.
  • Low (pLDDT 50-70) Use with caution; this region may be flexible or uncertain.
  • Very low (pLDDT < 50) Often disordered or not confidently placed.
Name 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
hTERT L866Y
hTERT V867A
hTERT V867T
hTERT V867M

Version:20260603

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

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