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Reference: Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.

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Polymerase	Reference	Property	Result	Context
T4 I50L	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	100 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 64[KD]uplication	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	50 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 N84K	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	100 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 271[L]uplication	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	74 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 V355A	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	5 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 Q380K	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	5 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 E395K	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	14 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 L412M	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	9 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 E743K	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	11 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 S756P	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	13 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 L771F	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	0.3 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 L771H	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	8 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 [L771+D]	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	29 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 [L771+V]	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	22 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay
T4 G255S	Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activities.	Nucleotide Substitution Rate	58 Mutation frequency (relative to WT)	Technique: T4 rII 199oc reversion assay