Synthesis and DNA polymerase alpha and beta inhibitory activity of alkyl p-coumarates and related compounds.

Nishimura K, Takenaka Y, Kishi M, Tanahashi T, Yoshida H, Okuda C, Mizushina Y
Chem Pharm Bull (Tokyo) (2009), Volume 57, Page 476
PubMed entry

Abstract:

trans- and cis-Icosyl, docosyl, and tetracosyl p-coumarates, ...
trans- and cis-Icosyl, docosyl, and tetracosyl p-coumarates, constituents of Artemisia annua L., and their structurally-related compounds were synthesized and evaluated for inhibitory activity on DNA polymerases alpha and beta. Among 30 compounds synthesized, octadecyl trans- and cis-p-coumarates and octadecyl p-hydroxyphenylpropiolate showed strong inhibitory activity on DNA polymerases alpha and beta.

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