[Association between high activity of DNA polymerase iota and the development of human uveal melanoma].

Gening LV, Grishina EE, Petrochenkov AN, Tarantul VZ
Genetika (2006), Volume 42, Page 98
PubMed entry

Abstract:

Enzymatic activity of DNA polymerase iota (Pol t) was analyzed in ...
Enzymatic activity of DNA polymerase iota (Pol t) was analyzed in human uveal melanoma cell extracts, using an earlier elaborated approach. The Pol t activity was observed in seven out of eight malignant tumors, while it was absent in the normal uveal tract cells of the same patients. These findings serve as an additional confirmation of the Pol t oncogenic potential.

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