Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.

Cao S, Gao Z, Thomas SJ, Hecht SM, Lazo JS, Kingston DG
J Nat Prod (2004), Volume 67, Page 1716
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Abstract:

Bioassay-directed fractionation of an extract of the marine species ...
Bioassay-directed fractionation of an extract of the marine species Spongia sp. led to the discovery of the new sesquiterpenoid derivative 17-O-isoprenyldictyoceratin-C (1), the known sesquiterpenoid derivative dictyoceratin-C (2), and the sesquiterpenoid quinone ilimaquinone (3), in addition to the nucleoside 2'-deoxyuridine. The structure of the new compound 1 was determined on the basis of spectroscopic methods and by conversion of dictyoceratin-C (2) to 1.

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