Synthesis of non-natural DNA using DNA polymerase.

Ebara Y, Sugiyama T, Kaihatsu K, Ueji S
Nucleic Acids Symp Ser (2000), Volume , Page 143
PubMed entry

Abstract:

Nonnatural nucleotide modified by glucose or galactose was synthesized ...
Nonnatural nucleotide modified by glucose or galactose was synthesized to increase functional diversity of DNA library. These compounds were incorporated in a DNA double strand using Klenow Fragment as well as dTTP. These functional group could be ordered sequentially on a DNA double strand at intervals of few angstroms according to the designed template sequence within a few hours. This method must be useful to constructing nonnatural DNA library or designed supramolecular structures.

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